In a dream episode during Thanksgiving 2008, Maxie meets Matt and asks him if she's sure they hadn't met before, even asking, "did we go to high school together?" Their portrayors Kirsten Storms and Jason Cook had previously played High School Sweet Hearts, Shawn and Belle, on Days of Our Lives. Additionally, Matt and Maxie met by bumping into each other which is how Shawn and Belle first met.
Similarly when Sam McCall and John McBain meet. Both actors played vampire lovers on the short-lived supernatural spin-off of General Hospital, Port Charles.
A recent storyline took it a step further, having the man playing McBain reprise the role he portrayed on Port Charles.
Another example came in a scene involving Franco and Kiki. Kristen Alderson, who originated the role, announced her departure; her final scene was with Roger Howarth, who had worked with Alderson on One Life to Live as Todd Manning and his daughter Starr respectively. As they had worked together since she was 6 years old, they were coworkers for the better part of two decades. As such, the dialogue of their last scene, written on the surface as Franco rambling after a dose of LSD, could also be intrepreted as Todd saying goodbye to Starr and in turn, Howarth saying goodbye to Alderson.
The Cast Showoff: The Nurses' Ball tended to do this plenty of times, most notably with Jack Wagner and Rick Springfield (furthering both of their singing careers) and Kelly Monaco (using her experience on Dancing with the Stars). The show practially started Richard Simmons career. He was a fitness instructor at the Campus Disco in 1978-1979
Dr. Steve Hardy, when actor John Beradino passed away from pancreatic cancer in 1996, was written out as having suffered a fatal heart attack. Hardy, whom Beradino had portrayed since the show's beginning in 1963, remained in the opening montage as late as December 1997.
Anna Lee's Lila Quartermaine and John Ingle's Edward Quartermaine.
Emily McLaughlin's Jessie Brewer, although Jessie had been Out of Focus for years due to Emily's declining health, and Jessie's passing wasn't acknowledged within the show until the 30th anniversary episode, two years after McLaughlin's death.
Rosalind Cash died of cancer in October 1995. Her character, Mary Mae Ward, died of a heart attack in January 1996.
Fake Irish: Oregonian Erin Chambers plays Siobhan with an extremely thick accent that sounds as fake as it is.
Keep Circulating the Tapes: Most episodes of General Hospital from 1963-1978 are extremely rare (especially the early color episodes from 1967-1975 which some are extinct) and exist only in B&W Kinescopes. Also being a soap opera and with SOAP Net defunct there is no way to catch reruns.
30th: A revisiting of the events of the first episode, also debuting a new opening sequence and theme song, replace the ones used since 1975/1978, which would be used until 2004.
35th: A primetime special, chronicling the evolution of the show.
50th: The return of the Nurses' Ball after a 12 year absence, the reason was due to budget cuts in 2001.
51st: "Carlypalooza", past Carly's Sarah Brown and Tamara Braun returned; all three (including current Carly Laura Wright) alternated in scenes with Maurice Bernard.
52nd: Tying into current storylines, the episodes has scenes recreating the very first episode, with current cast members portraying the original roles.
Ooh, Me Accent's Slipping: Mac Scorpio's already dodgy Australian accent was pretty much dropped entirely within a few years of his first appearance. His brother Robert had a full Aussie accent right through. Mainly because Tristan Rogers(Robert) really is Australian, while John J. York(Mac) is not.
Lucky Spencer has had three different actors, and Carly has had four, with Carly #1 coming back as a different character with Carly #4 still around...
Michael's getting there: He's already had three actors play him, and he's not out of his teens yet.
Lucas Jones had 10 actors play him in total.
With the casting of Jen Lilley to temporarily replace an ailing Kirsten Storms, Maxie is now up to 4 (not counting her pre-SORASed baby actors, which would put her on par with her cousin Lucas).
In 2013, Julian Jerome (who supposedly died in 1988) was revived, played by William De Vry, known for his work on All My Children, where he played one of the most sadistic villains in soap history, Michael Cambias. Coincidentally, Lucky #2 was played by fellow AMC alum, Jacob Young, prior to his role as JR Chandler (and in another coincidence, both actors have had stints on The Boldand The Beautiful, De Vry's after his AMC run, Young's before and after his).
The most recent change took place in 2014, as the character of Jason Morgan returned after a 23-month absence, this time portrayed by Billy Miller, best known for his work on The Young and the Restless, which coincidentally also stars Steve Burton, the previous actor.
Edward Quartermaine was originated by David Lewis, before John Ingle took over in 1993. Les Tremayne and Jed Allan have also played the part, although the character died with Ingle.
Romance on the Set: Wally Kurth (Ned Ashton) and Rena Sofer (Lois Cerullo) off-screen relationship paralleled their on-screen one—friendship, marriage, pregnancy. . .separation and divorce.
Jack Wagner and Kristina Crump (Malandro) married in 1993, seven years after their characters (Frisco and Felicia) married on the show.
Too Soon: Luis Alcazar fell out of the window at least 10 stories high and the fall was shown from the outside. This scene took place a year after the 9/11 attacks. Admittedly, they did learn their lesson; Trevor Lansing's death by fall from a similar height in 2009 was not shown.