These are what we call the 'YMMV items.' Things that some people find in this work. We call them 'your mileage might vary' because not everyone sees these things in the same way. This starts discussions in the trope lists, a thing we don't want. Please use the discussion page if you'd like to discuss any of these items.
Arguably Carly when Tony Jones kidnapped Michael. Granted, Sarah Brown is an excellent enough actress that it was easy to feel sorry for Carly, but what led up to the kidnapping was all Carly's fault. She'd spent a great deal of time emotionally manipulating Tony, letting him believe she loved him, but she only went after him to ruin Bobbie's life. Then Carly got pregnant and told Tony he was the father. She allowed Tony to get an emotional attachment to Michael while he was still in the womb and Tony loved the baby. But the minute Carly thought Jason was Michael's father and not Tony, she dumped him and immediately moved on with Jason. And despite wrecking his marriage to Bobbie for Carly and genuinely loving the child she carried, Tony was told repeatedly by many people to just get over it and move on with his life. With that kind of emotional manipulation, a blowup was bound to happen.
Better as Friends - Spinelli and Maxie, Jason and Carly, though their respective pairings have their own fans. Spixie fans WILL go nuts if you bring this up. They will. Don't push it.
Broken Base - Bob Guza's third and longest run as head writer from 2002 to 2011 (with at different points a couple of co-head writers), which is arguably the most controversial run by a head writer in American soap history besides James E. Reilly for Days of Our Lives. It has its vocal defenders, especially among fans of Jason, Sam, and Sonny, but others - mostly longtime fans who at least started watching the show in the '90s - criticized it for shifting the focus of the show toward the mob, killing off (and violently, at that) members of the longtime Quartermaine and Jones families while ignoring or writing out well-established characters, and for more than a few blatant cases of Black Hole Sue and Creator's Pet. Whether or not you defend Guza, it's really telling that with the radical regime change in showrunners in 2012 and with the fear of cancellation overhead, all the mob-oriented characters except Sonny have been killed or sent to prison (although more mob characters have appeared or returned since), many established characters written off years ago have returned, and the Quartermaines have been made a strong center of the show again.
Creator's Pet - Several, but many fans agree they would like to forget Courtney ever existed.
Thanks to a Broken Base, this is what half the fandom thinks is happening whenever Spinelli hits the screen.
Brenda Barrett. Soulmated to two leading men? Check. Everyone falls at her feet whenever she returns to Port Charles? Check. Constantly compared to and held on an eternal high pedestal? Check. Always seen as a good guy and victimized? Check. Any character who doesn't like her is turned into an instant villain? Check.
Designated Villain: Arguably Lucky and Sam were this when Elizabeth and Jason became a couple. It almost seemed like the show couldn't sell Jason and Elizabeth as a couple without wrecking these other two characters. Long story short—Elizabeth and Jason had a one-night stand which conceived Jake. Though both obviously still had feelings for each other, they decided to go back to Lucky and Sam respectively and Elizabeth decided to pass Jake off as Lucky's son. Eventually Sam found out the truth and got rightfully angry. But to make viewers feel zero sympathy for Sam, a whole ton of retconning was done. Her con-artist past was changed so that she became a total slut as opposed to trying to support her half-brother. And she was made primarily responsible for Jake's first kidnapping, though another woman did it!! Later on she hired armed thugs to harass Elizabeth and her children to "remind" Elizabeth how dangerous Jason really was, and when Jason found out he threatened to kill Sam.
Then there was Lucky, who arguably was the most victimized in this situation. But viewers weren't allowed to feel sympathy for him either. Despite being Luke Spencer's son and quite intelligent, he was dumbed down and made to look like a fool. Not to mention when Elizabeth and him finally divorced he was made the bad guy—by having an affair with Sam!! Never mind that Elizabeth was knowingly passing off another man's child as Lucky's and had been pining for this other man!! But Elizabeth was made to look like a victim by the writers and she turned her nose up at Lucky and Sam for all their misdeeds.
Die for Our Ship - The current most hot one is creating a fully Broken Base: the Spixies will die for their ship, while the Free Maxies will die for anything but. Except for two Spinellis.
Fan-Preferred Couple - Luke and Laura, right from the beginning. Some might debate Liz/Jason, but that's why this is YMMV.
Hilarious in Hindsight - Three days after Ryan Carnes left the show and the role of Lucas Jones was given to Ben Hogestyn, the character came out of the closet. If Ryan had stayed on the show for another three days, he would have played his third gay character in a row. Ironically he left to play a character on Desperate Housewives - who is also gay.
Hollywood Homely: Sabrina Santiago is described as frumpy and undesirable by giving her huge red glasses and frizzy hair. Of course, she's following in the grand tradition of Lucy Coe, who was a mousy librarian type before she got her vamp makeover. Winnifred Leeds would be another character in the same vein (though she never got a makeover like Lucy and Sabrina did.)
Ho Yay: A lot during the years but taken to new heights by Franco's obsession with Jason.
Jason with guys in general, as expressed in this video.
Hypocrite: Sonny cheated on Carly numerous times during their marriage. This included Alexis and Sam, both of whom became pregnant with Sonny's children, and did some emotional cheating with Brenda. Carly forgave Sonny for all of these indiscretions. But when Sonny found out that Carly had known that Alexis's daughter Kristina was his daughter as well, he immediately demanded a divorce and railroaded her for her betrayal.
Mob hit-man Jason lecturing his stepmother Monica about "doing the right thing" and confessing to being responsible for Sam's hit-and-run. More frustrating was that he only cared about Monica telling the truth because Elizabeth had been the prime suspect and he was more worried about clearing her name.
Carly herself. Aside from being an all-over horrible person, she slept with Jason for weeks without even knowing his name, seduced her stepfather Tony then cheated on him, married AJ, then cheated on him with Sonny—has probably cheated on every man she's ever been married to or involved with. But verbally and physically assaults any woman who dares to so much as TALK to a man she's interested in, branding them a "slut" or "tramp". As well, she spent nine months passing off a child who knew might not be Tony's off as his, then spent years keeping AJ's son away from him—but blasted Liz for doing the same thing with Jason.
Moral Event Horizon: Morgan knocking his brother Michael out, and leaving him to drown at Pier 52 while his ex-wife (Michael's current girlfriend) watches.
Purity Sue - Jason, before and after the accident.
The irony of this is that Jason's portrayer, Steve Burton, actually asked for the radical change in personality, as he was tired of playing such a Purity Sue character—straight-A pre-med student, steady girlfriend, varsity athlete, community activist, etc. Only to have Jason Morgan, a mobster's errand boy/hitman, be essentially viewed the same way by the writers and other characters alike.
The Untwist: Weeks were spent setting up the murder of Asshole Victim Damian Smith, with numerous people denouncing and threatening him—several of whom even physically assaulted him for his amoral conduct. When his head was finally bashed in, the killer was quickly revealed to be the person who had been the angriest at him and was the last person viewers saw arguing with him. That said, he was still a Sympathetic Murderer—he didn't even mean to kill the guy, just stop him from torching his house.