- The ending to Case 6, specifically the moment when you have to arrest the not-corrupt cop.
Jones: ...(player's name), can you handle the arrest, please? I don't have the heart to read him his rights.
- It's even worse when it's revealed that the cop had killed his partner in the heat of the moment, and he was extremely upset for doing so. He regretted leaving his partner's children without a father, and having to spend time in jail meant that he'd also be away from his family. Since he pleaded guilty to the crime, though, he only has a four year sentence with parole eligibility in two years but he likely would never have a job as an officer again.
- The revelation of One-tooth Sam's back-story in Case 11, especially the death of his wife which led him to renounce his former wealth.
One-tooth Sam: My wife got sick, and even all the money in the world couldn't save her.
- Case 18 becomes this when you have to arrest a young boy who killed his friend by accident. The boy is in tears over what he's done, and Jones gets upset as well.
- Case 21's victim Rachel Priest died standing up on truth and justice moments before her death, all while scattering clues for you to find knowing that she's not long on this earth. Jones is upset and goes It's Personal the entire case, knowing that despite Rachel was incredibly nosy, stubborn, troublesome, and a little callous to her co-workers in several previous cases, he knows that she's a loyal and diligent defender of justice whose death is largely because of her cameraman sold her life work to her murderer. When a later case reveals her murderer gets out of the jail with $ 5000 because of "procedure violation", Jones quickly demands Chief King why the murderer is free once again, but Chief says police is powerless against judicial bureaucracy.
- Case 23's victim was one of the few victims in this series to completely avert Asshole Victim. His only "fault" was his desire to leave Grimsborough and travel, yet someone still finds a reason to kill him. This is Lampshaded by Jones and a few other characters as well.
Jones: I don't know about you, <player>, but this case's quite bummed me out. All Daniel wanted to was travel the world and not restrict himself to our little town. But Lily was so attached to her roots that she couldn't bear the thought of Daniel not wanting the same life as she did...
- Case 28's Motive Rant, when you arrest the killer. Her husband, the victim, had caused their infant child's death by negligence, and then tried to cover it up by saying the house was haunted and that that was what killed the child.
Killer: Whatever punishment you give me cannot be worse than the cruel fate of losing your child!
- The reaction of James Savage, the local Misunderstood Loner with a Heart of Gold, when his dog is killed in Case 31.
Savage: I met that dog when it was just a puppy. It'd been thrown in a ditch. I saved his life, and it rewarded me by staying by my side for 10 years. It never bit anyone, never growled at people. And now... now my best friend is dead!
- Case 31 is just heartbreaking for anyone who loves animals, especially dogs.
- The ending of Case 51, in which Chief King gives the player character a tearful farewell before shooting himself after being outed as the killer, despite Jones begging him to put the gun down.
King: Goodbye, (player's name). Working with you has been a great honor. BANG
- The ending of Case 56 brings quite a lot of tears in the fans' eyes as they are to part with the Grimsborough team because the Player Character is moving to Pacific Bay.
- In the finale of White Peaks, Amy remarks that the killer couldn't be her mother, because she loves her and Duncan. Then she revises it, and says she only loves Duncan.
- In the climax of that very same case, during the confrontation with the killer, Amy was so deep in denial that she almost concedes when the killer tried to convince her that this is a false arrest, until Hannah arrives with a video footage of the murder itself. Note that when her high school sweetheart tried to pull the same trick two Cases before, she angrily rebuffs his attempts to lie by saying that the [Player Character] is never wrong.
- Some murders are Accidental Murder, and at times, the murderers genuinely regret their deed. Some of them were even crying or look saddened when they're arrested, such as the murderer in Case 48 "Good Girls Don't Die".
- Case 56 of Pacific Bay is entitled "A Killer Among Us". As the case name implies, there's an unrest in the PBPD as someone from the team is hinted to be a traitor. 4 team members are flagged as suspects for Danny Moto's murder and Frank Knight was ultimately revealed as the killer.
- All three cases of The Wastes are tearjerkers. First one's victim was just trying to stop the killer from doing experiments that can destroy the city. Secondly, Karen Knight is murdered, and while we hated her, she was good, all along, and helping us. And the last case has our beloved partner, Frank Knight as the victim. And it is the last case as well, so say your goodbyes to Pacific Bay.
- Three words. The Final Countdown. The victim was Frank Knight, who at the ends, realized his mistakes and gives his life for Pacific Bay. More so, we found a recording of him addressed to us, where he said he tried very hard to fix his mistakes. Amy remarked that it was as worse as seeing Frank being murdered in the camera. Also, one of the clues was Frank's police badge. He kept it all the time with him, Amy remarked that he was a cop at heart all that time.
- Frank's funeral is guaranteed to bring a tear to your eye especially after everything that happened in The Wastes. After everything that's happened within the last cases, Chief Marquez still takes care of his funeral arrangements and the team comes together one last time to lay him to rest and share their sentiments.
- Case 20 of World Edition. Not only was the victim a goodhearted cop, but the killer turned out to be his beloved sister, who shot him by accident when she thought she was going to get mugged by a stranger. When she realized what she'd done, she breaks down in tears and tries to avoid going to jail because that wasn't what her brother would've wanted. Judge Adaku gives her a lenient sentence, but the guilt of the crime would stay with her for life.
- Case 21 of "World Edition" opens with Jack complaining that he feels utterly useless against the plague and how worried he is for Angela and Lars. Lars coming in utterly sleep-deprived doesn't help.
- And in the same case, it's heartbreaking to see Lars infected by the virus and only has a few hours at best. The reaction of Angela and Jack make it worse; both of them are crying.
- The entirety of Sanjay's appearance in Case 24 of World Edition. The player finds him in Tibet, which he ran off to after his pet elephant was killed in an accident. He is penniless and all alone, and gets caught in an avalanche when trying to find a job. He is taken to the Bureau to recover, but in the AI it's never revealed where he went afterwards.
Tear Jerker / Criminal Case
Sorrow-inducing moments in Criminal Case: