History TearJerker / CriminalCase

* In ''The Secret Experiments'', Rachel Priest died standing up for truth and justice moments before her death, all while scattering clues for you to find knowing that she's not long on this earth. Jones is upset and goes ItsPersonal the entire case, knowing that despite Rachel being incredibly nosy, stubborn, troublesome, and a little callous to her co-workers in several previous cases, he knows that she's a loyal and diligent defender of justice whose death is largely because of her cameraman sold her life work to her murderer. When a later case reveals her murderer gets out of jail with $ 5000 because of "procedure violation", Jones quickly asks Chief King why the murderer is free once again, but the Chief says the police are powerless against judicial bureaucracy.

--> '''Jones:''' I don't know about you, <player>, but this case's quite bummed me out. All Daniel wanted to was travel the world and not restrict himself to our little town. But Lily was so attached to her roots that she couldn't bear the thought of Daniel not wanting the same life as she did...
* The MotiveRant in ''The Haunting of Elm Manor'', when you arrest the killer. Her husband, the victim, had caused their infant child's death by negligence, and then tried to cover it up by saying the house was haunted and that that was what killed the child.

** It's even worse when it's revealed that the cop had killed his partner in the heat of the moment, and he was extremely upset for doing so. He regretted leaving his partner's children without a father, and having to spend time in jail meant that he'd also be away from his family. Since he pleaded guilty to the crime, though, he only has a four year sentence with parole eligibility in two years but he likely would never have a job as an officer again.

* In ''The Secret Experiments'', Rachel Priest died standing up on truth and justice moments before her death, all while scattering clues for you to find knowing that she's not long on this earth. Jones is upset and goes ItsPersonal the entire case, knowing that despite Rachel was incredibly nosy, stubborn, troublesome, and a little callous to her co-workers in several previous cases, he knows that she's a loyal and diligent defender of justice whose death is largely because of her cameraman sold her life work to her murderer. When a later case reveals her murderer gets out of the jail with $ 5000 because of "procedure violation", Jones quickly demands Chief King why the murderer is free once again, but Chief says police is powerless against judicial bureaucracy.

** Jones' face after the shot can also be considered one. His look is just lost, shocked, unable to react anymore.

* ''The White Peaks Project''. Not only does the victim, unusually for Criminal Case, ''completely'' averts being an AssholeVictim, her death was a horrible accident, and her last words are directed at the player character, pleading them to find her killer. On top of it all, she was a close friend of Amy.

** In the climax of that very same case, during the confrontation with the killer, Amy was so deep in denial that she almost concedes when the killer tried to convince her that this is a false arrest until Hannah arrives with video footage of the murder itself. Note that when her high school sweetheart tried to pull the same trick two Cases before, she angrily rebuffs ''his'' attempts to lie by saying that the [Player Character] is never wrong.
* Case 56 of Pacific Bay is entitled "A Killer Among Us". As the case name implies, there's unrest in the PBPD as someone from the team is hinted to be a traitor. 4 team members are flagged as suspects for Danny Moto's murder and Frank Knight was ultimately revealed as the killer.
* All three cases of [[PollutedWasteland The Wastes]] are tearjerkers. First one's victim was just trying to stop the killer from doing experiments that can destroy the city. Secondly, Karen Knight is murdered, and while we hated her, she was good, all along, and helping us. And the last case has our beloved partner, Frank Knight as the victim. And it is the last case as well, so say your goodbyes to Pacific Bay.
* Three words. The Final Countdown. The victim was Frank Knight, who at the end, realized his mistakes and gives his life for Pacific Bay. More so, we found a recording of him addressed to us, where he said he tried very hard to fix his mistakes. Amy remarked that it was as worse as seeing Frank being murdered in the camera. Also, one of the clues was Frank's police badge. He kept it all the time with him, Amy remarked that he was a cop at heart all that time.
* [[https://www.youtube.com/watch?t=18&v=GcaJA6QhxUs Frank's funeral]] is guaranteed to bring a tear to your eye especially after everything that happened in The Wastes. After everything that's happened within the last cases, Chief Marquez still takes care of his funeral arrangements and the team comes together one last time to lay him to rest and share their sentiments.

* Chief Ripley's supposed death in ''The Impossible Dream'', not made any easier by Jack being in denial about it.
* ''Treacherous Waters''. Not only was the victim a goodhearted cop, but the killer turned out to be his beloved sister, who shot him by accident when she thought she was going to get mugged by a stranger. When she realized what she'd done, she breaks down in tears and tries to avoid going to jail because that wasn't what her brother would've wanted. Judge Adaku gives her a lenient sentence, but the guilt of the crime would stay with her for life.

** And in the same case, it's heartbreaking to see Lars infected by the virus and only has a few hours at best. The reaction of Angela and Jack make it worse; both of them are crying.
* The entirety of Sanjay's appearance in ''Insides Out''. The player finds him in Tibet, which he ran off to after his pet elephant was killed in an accident. He is penniless and all alone, and gets caught in an avalanche when trying to find a job. He is taken to the Bureau to recover, but in the AI it's never revealed where he went afterwards. [[note]] (It's eventually revealed that he went to Beijing, China in ''A Twist of Fate''. But still) [[/note]]

* At the end of ''A Stab in the Dark'', Elliot is kidnapped by a SOMBRA agent. The entire team is frantic to get him back and both Lars and Carmen look literally sick at the idea that he's dead, with Carmen [[NeverSayDie outright cutting Lars off before he can finish his assessment on why the kidnapper would have discarded the gag he was using.]]

* The ''entire district'' of Africa is one, since the Bureau finds out that a member of their own team had given SOMBRA the coordinates of their plane to Kenya which allowed a hitman to make it crash, essentially revealing that [[TheMole there's a traitor among them]]. Naturally, a good bulk of the district's StoryArc focuses on finding out who is it while the traitor keeps sabotaging The Bureau's equipment and security, to the point the Additional Investigations of Africa are aptly titled "The Enemy Within". Seeing your friends and teammates becoming increasingly paranoid and distrustful of each other as the district goes on is just heartbreaking to see.

* ''In Plain Sight''. ''[[WhamEpisode All of it]]''. Being the district's finale of Africa and having the victim killed inside the team's headquarters, it was expected that this case would focus on finally uncovering who the traitor is, something that was bound to bring bitter moments. A good portion of the team, including [[TheLancer Jack]], [[TeamMom Carmen]], and even [[DaChief Chief Ripley]], end up becoming suspects. As the case goes on, you can feel the tension and despair beginning to arise among the team, with people starting to accuse each other either in anger, fear, or in the culprit's case, desperation of being caught, which is quite sad to see considering how united the Bureau has been for the rest of the season.

** Even [[ComedicHero Jack]] gets this after he becomes a suspect due to his gun being used as the murder weapon. Not only he's still hurt after his break-up with Asal (to the point he reveals [[SexForSolace Lavinia manipulated him to have sex with her back in Kenya]]), but like Elliot, he doesn't take very well being flagged as a suspect and traitor not only by a former member of SOMBRA, but by his best friend as well.

*** During her arrest, Angela reveals that, while she did provide the plane's coordinates in the first case of Africa to SOMBRA, she didn't actually expect them ''to make their plane crash'' at all. [[YouHaveOutlivedYourUsefulness Realizing that SOMBRA wanted her dead]] due to probably [[BecomingTheMask becoming too attached to the Bureau]], she ended up making a last-ditch effort to prove her loyalty by arranging the diamond smuggling operation the team had been investigating across the continent in the first place. Then during the AI, Angela says that she regrets nothing and is still believes in SOMBRA despite their horrible actions. It's just saddening to see that even when being almost killed by the very same organization she had been willing to commit crimes for, Angela continued being [[UndyingLoyalty loyal to them until the end]] despite already having a loving family and group of friends in the Bureau.

* In ''Murder, He Wrote'', Lars returns but he's in still in a very bad way after Angela's betrayal. And at the end of the second chapter, he threatens suicide.

* IceQueen Ingrid used to be married, and the end of it was so devastating she can't compose herself. When her ex-husband is trying to contact her because of some serious problems the Bureau needs to be aware of, she breaks down and runs away.

** The player finds the body of Natasha Romanova, leading to some conflicting emotions from her daughter, Marina. While she had helped arrest Natasha for treachery and still believes that she's evil, it's clear that she still wants to grieve for her mother. However, she doesn't get much time to grieve as she's immediately arrested for being related to Natasha (who had kidnapped the US President).

** Angela also returns as a suspect, and her presence stirs up emotions in both Jack and Lars. Both are angry that she would show her face at the Bureau after all she did to them, and are fiercely protective of each other in her presence. When she detonates a bomb that nearly kills Jonah and Jack, Lars confronts her while she states that all she wanted was to see her family again. She is later proven innocent of kidnapping and murder, but shares one last conversation with Lars. Lars admits that after she was arrested, all he wanted was for her to have a change of heart and be in love with him again, and while she confirms that she still loves him, Lars coldly remarks that he knows who she really is and only loves the woman he thought he knew. After he denies Angela's request to see their daughters again, she tearfully bids him and the player goodbye.
** When it's time to arrest the killer, Armand Dupont asks if he could help Jack and the player do the honors. They corner the Vice President, and she takes a shot at Jack. When it doesn't kill him, she takes another shot at him...only for Armand to jump in front of Jack and take the bullet. Jack then shoots the VP dead in retaliation, and Armand is rushed to the hospital, where he only has a few more hours to live. Jack tearfully apologizes for not being able to protect him, but Armand reassures him that he had great adventures with the Bureau, and made peace with the fact that he would die saving the world. He gives the player his ancestor's notebook (the key to Season 4), and thanks them for always listening to his ramblings. After seeing the UN Peace Award they won, he passes away peacefully, and the entire Bureau has heartfelt things to say to him during his funeral.
** Chief Ripley's last appearance. The only time she appears in this case is at Dupont's grave, after everyone had left. She apologizes to him for his life having ended this way, and bids farewell to her old friend.

* ''Let Me Down Gently'' features Lucrezia Capecchi who is dismissed and disparaged by just about everyone including her sister for her facial burns, had some painful EnforcedMethodActing from a bitch of a movie director, and ultimately died when she was to meet her correspondence partner at a lighthouse party, who didn't want to be involved with her. When she grabbed him to stay, he reacted and she fell out of the lighthouse to her death. Poor judgment, but still a tragic end to an even more tragic story.

* ''Snake in the Grass'' has Jones and the player character investigate the murder of Nathan Pandit who was the coroner of the first season. It's tearjerking as it's the first case in and a death of a friend has already occurred.

* ''Too Cruel for School'' sees the return of Julian Ramis from the first Grimsborough arc, who is ostracized due to accidentally killing his friend five years ago and has untreated depression as a result. When he first sees the player character again, he thinks they've come back to ruin his life.
** The very next case, ''Hear My Cry'', has Edward Ramis, Julian's dad as the victim of the Rocket Cow Killer. Not only is Julian devastated when the player breaks the news to him, but he reveals that he [[PartingWordsRegret had an argument with his dad right before he died]], which prompted the killer to target him in the first place. Not helping matters is the fact that Edward was mostly a loving and supportive father to Julian, and was implied to be the only support he had left after the AccidentalMurder five years ago.
* A missing person's case for a social worker named Zoe comes through the department, and surprisingly, the data on it is missing. It's revealed that for some reason, Jones was the last person to talk to it. When Gloria and the player confront him, he's evasive, chalking it up to a failure on his part. However, digging deeper, the truth is realized: Zoe is Jones's girlfriend, his first serious encounter after his flirting with Rachel Priest[[note]]Who died horrifically, not to mention Jones blames himself for the death.[[/note]] The player tracks down the disappearances throughout the Additional investigation. She's found in the penultimate case, but she has amnesia. To the point where she no longer remembers Jones.

* ''Things Fall Apart'' has lab chief Rupert, one of the nicest characters in the season, as the victim. Despite all the planning the team did to disguise him as Mortimer Pickering before entering Dreamlife's dome before, it didn't stop Rupert's identity from being compromised and killed. The killer turns out to be the Dome's local therapist, who, having dated the real Pickering back in Oxford, saw past Rupert's identity when he couldn't remember who she was.

** The funeral is also a big tearjerker. They start to tell stories about him and how much he will be missed in the office with his antics, and do promise to bring Dreamlife down, but it doesn't hurt any less.

* Barb Bellamy and Wendy Stokes are killed off two cases apart, doubles as Heartwarming as the lovers are now back together in death.
* In ''Up in Flames'', the death of Tony Marconi is incredibly depressing for many fans, especially since he had been an important character since the second case of the game, and a character many held dear to their hearts. It doesn't help that he died trying to stop Protozane from being shipped out to the public, which would've turned the entirety of Grimsborough into mindless sheep. Throughout the case, it is mentioned that Marconi wanted to reconnect with his son, Emilio Fuller and would do anything to protect him, even doing dirty work for Rozetta after she blackmailed him with Emilio. Unfortunately for him, Emilio despised his father and refused to listen to him, even killing him because he genuinely believed that Dreamlife would make the world better and couldn't stand it when Marconi was trying to stop its work.

* In ''Pain in the Neck'', we see Julian Ramis for the first time since his father's death, where he is aspiring to attend Grimsborough University. While he is initially cold towards both the player and the investigation, he later reveals that he had told the victim that he wanted to apply to the University, but he laughed at Julian, saying that a criminal like him has no future. Julian bursts into tears as he tells the player about this, then says that his life is cursed anyway.

* In ''Like a Pig to the Slaughter'', the victim is Roy Loukas, Mia's father. When the team breaks the news to her, she breaks down crying, and later recalls the argument they had right before he died. In court, she also has to hear the killer accuse her dad of ruining his life, which causes her to run away from the police station.
* ''To Kingdom Come'' has rookie cop Mia Loukas killed in a car bombing. Not only does the team openly grieve her death during the investigation, but the circumstances of the murder make things even worse. Mia is one of the ''very'' few victims in the series to completely avert AssholeVictim, and the killer actually loved Mia and never intended to hurt her, but was given an order by Ad Astra to kill the player by rigging their patrol car with a bomb. Unfortunately for him, Mia was the one who triggered the explosion by borrowing the player's car yet again, resulting in her death.
* ''Out of Breath'' becomes this after you arrest the killer of Doris Black. It turns out to be Doris's brother, whose chances of being promoted in S.A.R.A. were ruined by Doris since she didn't want him going near the meteorite. He didn't believe her when she said it was dangerous, leading to the fight that killed her. During the trial, Clyde realizes that Doris was right about the meteorite, and laments about their ruined lives as he goes to jail.

** What seals the case's status is that the killer turns out to be ''Louis Leroux'', of all people. And you're told that he murdered her simply because she refused to let him get a scoop of her story, which had involved her accidentally gaining telekinetic powers.

** It gets even worse at the end of the case when Jones [[DrivenToSuicide downs a lethal dose of sedatives after saying goodbye to the player,]] being unable to cope with Zoe's death, alongside feeling like a failure as a cop. Thankfully he is saved in time, though it takes finding Zoe's therapy letters to Jones for him to regain the will to live and recover.
*** And even realistically that (one again) only works as a placebo effect. It's clear that he needs time off, so he is given an undefined leave until he truly recovers mentally to come back.
* While the murder in ''Playing Dead'' is rather gruesome and petty, it's hard not to feel bad for the killer, whose victim's ended up giving her the flu when she was pregnant, causing her to suffer a miscarriage.

** It becomes more saddening when you realize that most of the suspects didn't even have any ill-will towards Jake, not even the killer. The only suspect who had remotely any was his uncle who was peeved that Jake fired him (albeit for a justified reason) despite needing the financial help. Despite this, he still never even wished harm upon his nephew.
** And to add up to the sensation, this is the time Jones comes back after his undefined leave. Another person who knows '''EXACTLY''' what Gloria is feeling, therefore he may be one of the few people if not the only person in the group who genuely gets her.
*** And even with that, while we see him participate later on in some cases after an undefined leave, we see him pretty affected by it, still chocking up every time Zoe is mentioned.
* The revelation in ''To Eternity and Beyond'' that Denise Daniels is really Ad Astra's leader also reveals that Rozetta is really Denise Daniels' disowned daughter. Essentially, Rozetta was very much [[DesignerBabies a test-tube baby created by Denise as an experiment in the hopes that she would turn out as a superhuman]]. But Rozetta was the same as any other baby besides being taught a superiority complex, and completely disowned by the time she turned ten. While it doesn't justify Rozetta's actions, it does make you feel bad for the fact that not only was most of Rozetta's sheeple plot was instead her mother's teachings, but her estrangement, fear of her mother and her loneliness ended up in her creating Ad Astra.
* In ''Reap What You Sow'', the motive behind Joe Warren's murder of Christian Bateman is surprisingly tragic, and makes you feel bad for the Ad Astrans in spite of their status as a menace to the Grimsborough PD. It turns out that the Ad Astrans' superpowers were wreaking havoc on their bodies, and when Christian became sick and incoherent from overusing them, Joe [[MercyKill shot Christian to put him out of his misery]], as he couldn't bear to watch his friend suffer anymore.
* Despite being the ArcVillain for most of the season, [[OffingTheOffspring Rozetta Pierre being killed by Denise]] in ''Eve of Disaster'' is rather emotional, considering [[DeathEqualsRedemption she and the Ad Astrans agreed to help the player stop Denise]]. What makes it worse is the fact that not only did Denise never really care for her, but had used her and the Ad Astrans as pawns for her dirty work in the span of a year. Before that, the player finds a bracelet belonging to Rozetta with the initials of the Ad Astrans carved into the charms. Rozetta angrily demands it back, saying it's all she has left of her friends (two of whom are dead and the other two of whom were arrested). After that, she says that the Ad Astrans were the only family she'd ever had after Denise abandoned her.

* In ''A Greek Tragedy'', the killer of Pelagios turns out to be his wife Zosime, who is one of the nicest people the player ever encounters over the course of the game. The motive behind the murder makes it hard not to feel bad for her, because not only did the victim cause her unmanageable stress during her pregnancy, but he also tried to force her to have an abortion because he wanted a baby boy, but the baby would be a girl. Luckily for Zosime, she is allowed to avoid punishment because of her pregnancy, and the chapter ends on a high note.

* In ''Crime and Punishment'', Marina becomes a suspect for the death of her grandfather, Lev Romanov. When she pretends to be the press to gain some information, she witnesses Lev rudely scold his daughter, who is none other than Natasha. Marina easily recognized the tone, which is the same as to how Natasha treated her when Marina was still a child. When she tried to defend Natasha, Lev furiously sent her out of his room and ended their interview.
---> '''Marina :''' At one point, my grandfather's daughter walked in. .. my mother, who is only a child in this time period. And my grandfather flew off the handle! I recognized his tone instantly! It was the same kind of verbal abuse my mother would hurl at me! I just snapped! I wanted Romanov to stop mistreating his daughter the way she would one day mistreat me!
* In ''Pride Comes Before the Fall'', when Penelope had to break up with Alexandre to return to her duties in T.I.M.E. She was so heartbroken that she spent the rest of the case in her room.
* In ''Back to the Future'', Chief Scott ends up being the first victim of the Altered Present. While the player never really knew him, the other team members are all visibly distraught over his death, with Amy bursting into tears. Also, since this 2029 is vastly different from the one the rest of the team came from, everyone is worried about their loved ones back home and hoping they're okay.

* Out of all the members of T.I.M.E, Jack took Nebet's betrayal the hardest due to how close he was with her. He struggles to get over what happened and doesn't want to think about her.

* In ''Fool's Gold'', while the team has escaped the Altered Present, they didn't get to say goodbye to the Resistance (especially Isabelle and Sirius), who are now running for their lives to avoid execution by the Ptolemy guards.

* In ''Bewitched, Bothered, Bewildered'', the killer of Agwe turns out to be Jorge de la Cruz, who not only helped rescue the team just the previous episode but didn't even mean to kill the victim. He had fallen in love with the victim while the crew was waiting for Priestess Mabayo to awaken from her meditative sleep, but became frightened when the victim tried to kiss him (as homosexuality is seen as forbidden in the Age of Sail) and hit him with a bottle to scare him, only to end up killing him instead. In spite of feeling remorse for the murder, he is exiled to Skull Island as punishment.

* The Additional Investigation of ''Time's Up'' has Nebet start fading out of existence after confessing she learned during her time of exile how cruel her family had become after she altered history and her happiest moments were working for T.I.M.E. She went back [[HeroicSacrifice to stop her past self and Ammon from altering the course of history in the first place]]. Also, much like the finale of ''The Conspiracy'', there's an extra tearjerker, and it's the ending to this case since has you having to leave your old friends Jack, Marina and Amy for the second time before going back to 2019.

* In ''Mad World'', shortly after the killer Adam Enstrom is caught, he commits suicide due to his guilt over taking a human life. The circumstances behind this makes it even sadder, since in spite of Adam having been an ArtificialHuman, he had far more empathy than his creator did and cared for the other patients, and had never intended to murder Dr. Stein, only fix her sense of empathy. The team feels sorry for Adam and hold a proper funeral with him, fulfilling his eulogy wish.

** Priya goes missing just before the player discovers [[AssholeVictim Ruth Wu's]] body, and throughout the case, she insists that she had killed Ruth while transformed, and isn't having it when Gwen vows to prove her innocence.

** In the Additional Investigation, Hope and the player help the real Santa fix his GPS so he can deliver toys to children. However, when they return it to him, Hope suddenly asks if Santa knows who her real parents are, since she'd been raised by a guardian all her life. Santa admits that even he isn't sure, causing Hope to be dejected until Gwen gives her her Christmas present.
* In ''Weirder Stuff'', Ruby Rees (really [[NatureSpirit Rubarae]]) had fallen for Rex Logan in the hopes of conceiving a heir before she passes away. Instead, he had freaked out upon seeing her and vowed to kill her, resulting in her murdering him in retaliation. Luckily, [[PetTheDog Felix gives her an enchanted necklace allowing conception]].
* Priya doesn't take it well when she is banished from the pack after they discovered she joined them as a spy. She works to make amends to earn Zander's forgiveness during the Additional Investigation.
* Everything that Alice Kelly goes through in ''This American Death'' is heartbreaking. The team sees her being abused by the victim, her controlling husband, on camera, and Luke remarks that there's something off about her cheery attitude towards everything. She turns out to be her husband's killer, and reveals that she's actually a golem created by Dan Kelly to replace his wife, who he had murdered after she disobeyed him. When she confronted him after finding photos of her and Dan that she didn't remember, he threatened to kill her as well, which prompted the murder. She then asks the team to deactivate her since she had taken a life, and thanks the team for helping her before she turns back into inanimate clay.

* In ''Death at a Funeral'', Jacob is an inconsolable wreck after the events of the previous case, where the Demon Queen had taken the form of his thought-dead wife and Hope was left in a coma, which he blames himself for. He later sees a woman who looked like Lily from the back, and when he realizes his mistake, breaks down in tears.
* Bucky Johnson's death in ''To the Lighthouse'' is this for many players, who remembered him from ''Travel In Time'' as someone who helped the team achieve many of their goals in the 60s and even helped them stop WWIII. The worst part is, he manages to avert AssholeVictim and didn't deserve his fate.

* Despite Gwen's bad relationship with her mother Dolores, she is truly heartbroken when the latter becomes the victim of ''The Hunted Hunter''. During the investigation, its discovered that Dolores had attempted to extend an olive branch to her daughters. Even Ben admits that despite her nature, she died a rather cruel death.

** The stinger is that the killer killed Arthur because he had a change of heart about Earth's destruction, and tried to stop it from happening by draining his blood and giving it to Chief Arrow to stop the Queen's rising. However, he didn't know that Chief Arrow had turned over to the Queen under the impression that his late wife was still there, resulting in Chief Arrow giving Arthur's blood to the Queen anyway. ''Arthur died for nothing.''
** The discovery that Mathison, our friend from the FBI was a Queen's faithful demon in disguise the entire time, tasked to keep an eye on them after they had made contact with Arthur all the way back in ''One Bigfoot in the Grace'' was quite upsetting for both the team and players.

* The reason Jones becomes a suspect in the first place is because of a harsh message he sent to the victim. When he explains why this happened to you, all the sadness comes in: ''He was trying to move on from Zoe'' and try to find love again. He encountered the victim through an app and went on a date with this person, but the results were futile after the victim mocks him pretty badly, making him feel like an idiot.
* You can't but feel bad for Noemie Leprince after she learns she killed Celeste. Worst still, she had no choice because Antoine threatened her to do so or he'd make sure she can't model again.
* The breakup between Cody and Eleonora is really distressing, especially because of how bad Cody handles it.

* The Additional Investigation of Case 31 has Nebet start fading out of existence after confessing she learned during her time of exile how cruel her family had become after she altered history and her happiest moments were working for T.I.M.E. She went back [[HeroicSacrifice to stop her past self and Ammon from altering the course of history in the first place]]. Also, much like the finale of ''The Conspiracy'', there's an extra tearjerker, and it's the ending to this case since has you having to leave your old friends Jack, Marina and Amy for the second time before going back to 2019.

* In Case 4, Priya does not handle things well after she recovers from being a werewolf, only to find a dead werewolf on Ben's autopsy table. To make things worse, she is held at gunpoint by Ruth Wu later on.
* Gwen's sadness as she announces her official breakup with Pierce in Case 5, especially due to the two being on good terms despite Pierce being a vampire.
* In Case 9, shortly after the killer Adam Enstrom is caught, he commits suicide due to his guilt over taking a human life. The circumstances behind this makes it even sadder, since in spite of Adam having been an ArtificialHuman, he had far more empathy than his creator did and cared for the other patients, and had never intended to murder Dr. Stein, only fix her sense of empathy. The team feels sorry for Adam and hold a proper funeral with him, fulfilling his eulogy wish.
* In Case 10, we see Justine Bankston again after making peace with Abigail Riley's ghost. It is heavily implied that as the five years went by after she and her five friends sacrificed Abigail to a demon in a ritual, Justine matured into a TokenGoodTeammate and has been living with her guilt about it ever since. However, Gwen still breaks up with her, and the two part in tears.
* Case 11 has several sad moments:

* In Case 13, Ruby Rees (really [[NatureSpirit Rubarae]]) had fallen for Rex Logan in the hopes of conceiving a heir before she passes away. Instead, he had freaked out upon seeing her and vowed to kill her, resulting in her murdering him in retaliation. Luckily, [[PetTheDog Felix gives her an enchanted necklace allowing conception]].

* Everything that Alice Kelly goes through in Case 16 is heartbreaking. The team sees her being abused by the victim, her controlling husband, on camera, and Luke remarks that there's something off about her cheery attitude towards everything. She turns out to be her husband's killer, and reveals that she's actually a golem created by Dan Kelly to replace his wife, who he had murdered after she disobeyed him. When she confronted him after finding photos of her and Dan that she didn't remember, he threatened to kill her as well, which prompted the murder. She then asks the team to deactivate her since she had taken a life, and thanks the team for helping her before she turns back into inanimate clay.

* Case 20's killer's arrest, where it's revealed that Morgana Blackhawk took advantage of Heather Night and her desire to be accepted somewhere to coax her into killing Belinda. Although Heather feels guilty over what she's done, she is turned over to the authorities.
* In Case 26, Jacob is an inconsolable wreck after the events of the previous case, where the Demon Queen had taken the form of his thought-dead wife and Hope was left in a coma, which he blames himself for. He later sees a woman who looked like Lily from the back, and when he realizes his mistake, breaks down in tears.
* Bucky Johnson's death in Case 27 is this for many players, who remembered him from ''Travel In Time'' as someone who helped the team achieve many of their goals in the 60s and even helped them stop WWIII. The worst part is, he manages to avert AssholeVictim and didn't deserve his fate.

* Despite Gwen's bad relationship with her mother Dolores, she is truly heartbroken when the latter becomes the victim of Case 28. During the investigation, its discovered that Dolores had attempted to extend an olive branch to her daughters. Even Ben admits that despite her nature, she died a rather cruel death.
* Case 30 has a very sobering vibe throughout the main investigation. Arthur is found dead after going missing in the previous case, leaving the team distraught and unprotected in the depths of the Underworld. We also discover that Arthur had been dealing with a lot even when working with the Hunters-there was a bounty on his head, he had been trying to evade capture from the Queen's faithful and since he was trying to protect the hunters, [[StoicWoobie he didn't tell them about any of this and had been very much alone in all of it.]]

** The discovery that Mathison, our friend from the FBI was a Queen's faithful demon in disguise the entire time, tasked to keep an eye on them after they had made contact with Arthur all the way back in Case 2 was quite upsetting for both the team and players.

* Case 4. '''''Dear god'''''. Aside from being [[NauseaFuel extremely gruesome and gory]], and the fact that the victim is killed for a very petty reason [[{{Matricide}} by her own son]] (which is that she disagreed with his decision to turn the château into a bed and breakfast), what really makes it absolutely heartbreaking is High Commissioner Delacroix's reaction to her death, as he completely breaks down and is so brokenhearted that he must take the day off, [[FromBadToWorse but that's not all]]. It gets worse when in Chapter 3, the player eventually stumbles across Delacroix in the midst of the investigation, mourning the victim's death by singing while heavily drunk. He does get better at the end though, but the fact that the victim is Delacroix's ex-girlfriend and that she totally averts being an AssholeVictim despite her being a bit stubborn, [[TheWoobie is more than enough for players to really feel like giving poor Delacroix a hug]].

* Despite being the ArcVillain for most of the season, [[OffingTheOffspring Rozetta Pierre being killed by Denise]] in ''Eve of Disaster'' is rather emotional, considering [[DeathEqualsRedemption she and the Ad Astrans agreed to help the player stop Denise]]. What makes it worse is the fact that not only did Denise never really care for her, but had used her and the Ad Astrans as pawns for her dirty work in the span of a year.
** Before that, the player finds a bracelet belonging to Rozetta with the initials of the Ad Astrans carved into the charms. Rozetta angrily demands it back, saying it's all she has left of her friends (two of whom are dead and the other two of whom were arrested). After that, she says that the Ad Astrans were the only family she'd ever had after Denise abandoned her.
* In ''Blaze of Glory'', Rita sacrificing herself to save Grimsborough, with Martine calling Rita her best friend and her sister.

* In a meta sense. Having to leave David Jones again, as this was the second time we got to partner up with him, it can feel like you're leaving behind a close friend, especially after what he had to go through this season.

** It gets even worse at the end of the case when Jones [[DrivenToSuicide downs a lethal dose of sedatives after saying goodbye to the player.]] Being unable to cope with Zoe's death. Thankfully he is saved in time, though it takes needing to find Zoe's letter to Jones for him to regain the will to live and recover.

* ''Things Fall Apart'' has lab chief Rupert, one of the nicest characters in the season, as the victim. Despite all the planning the team did to disguise him as Mortimer Pickering before entering Dreamlife's dome before, it didn't stop Rupert's identity being compromised and killed. The killer turns out to be the Dome's local therapist, who, having dated the real Pickering back in Oxford, saw past Rupert's identity when he couldn't remember who she was.

** Also gets a bit worse when you put in mind that any kind of Police Job in the USA tends to retire at the age of 60 (65 if you're a chief), and he retires at the age of 40. That means that the events of the last time we saw him affected him more than one realize, to the point that the spark he found in the Force was possibly, completely gone.

*** What makes this case even more saddening, is that is pretty realistic in terms of meta and reality. We as the player, have seen him in his journey as a Police officer, ever since the first game. We saw his attitudes, mood changes, the way some of his teammates (and even the chief) treated him, Case 41 is still a thing, to then seeing King's suicide. And then you leave and come back later with a way tamer part of himself that lasts until we realize that he has been searching for Zoe for ''months'', only to find her without memories. His anger issues come back, slipping while trying to maintain positive, his reckless behavior causing trouble to the Force, him almost leaving everything behind... and then her death. He didn't attempt just because of Zoe, he attempted as a result of every single thing that happened to him compiled, causing a mess he felt he was the only one to blame. '''He was showing signs.''' And we as the player and the entire team saw that unravel and '''didn't realize in time''' until he was in the room and swallowed the sedatives, because they didn't think that he would actually collapse like that. Heck, not even Gabriel, the profiler, the person who found out about Julian's depression and helped him through it, thought that Jones would attempt. It's the harsh reality of someone battling suicidal ideations, and the team, and especially the player saw everything.

* In the AI of ''Breaking News'', Ad Astra use their new superpowers to take Jake and Carter Hayes hostage, taking them to Newmark while Gloria is helpless to stop them.

* Considering how much of a LovableAlphaBitch Madison Springer was, it can be sad in Case 41 where you have to solve her murder.

* In Case 13, Ruby Rees (really [[NatureSpirit Rubaera]]) had fallen for Rex Logan in the hopes of conceiving a heir before she passes away. Instead, he had freaked out upon seeing her and vowed to kill her, resulting in her murdering him in retaliation. Luckily, [[PetTheDog Felix gives her an enchanted necklace allowing conception]].