184: Helix cares for a pair of rabbits that, unbeknownst to him, Florence intends to eat. He names them Bun-Bun (from Sluggy Freelance) and Kevin (from Kevin & Kell).
185: Helix's comment in the last panel refers to the fact that, in ''Kevin & Kell, Kell once ate Jerry Springer Spaniel.
203: Helix's "Helix Vision" contains the code THX 1138, which George Lucas frequently inserts into his works as an in-joke.
410: Florence deduces that, because she's not in an enchanted castle, it's a dog and not an animated mop (from Disney's Beauty and the Beast).
440: Sam and Helix enter a movie theater called Thimble Theater. It shows cartoons, because its name comes from Thimble Theater, the comic strip that introduced Popeye. Sam and Helix will watch a Godzilla film.
441 to 451: There are cameos from several other webcomics. The captions under each strip identify the characters and their source comics.
When Rabbit Howls in 442, as well as referring to Kevin being a rabbit married to a wolf, is the title of a non-fiction book.
Every strip from 1390 to 1476 features a cameo. The robot religious meeting has robots from just about every TV series or film with robots, including Robbie, a Cylon, Astro Boy, a Skutter and K9.
1523: "Captain Sam's Super Secret Special Order 191." Found wrapped around three cigars in an envelope in the grass, no less.
1624: "My God, he's full of crickets!". 2001 of them, to be exact.
1683: When Sam needs to come up with an alias in a Cryogenics lab, he claims to be "Leonard Snart. Captain of this Cold facility." For those who don't get the joke, long time Flash villain Captain Cold's real name is Leonard Snart.
1694: The questionnaire Florence uses to see if her mind has been tampered with starts with a rather well-known question from Blade Runner.
2467: Dr. Bowman's first words to Florence echo the Ghost of Christmas Present's first words to Scrooge in A Christmas Carol. Dr. Bowman, who we already knew shared a name with a character from 2001: A Space Odyssey, is revealed to have much in common with another character from the same film.