Dead Like Me is a more realistic take on Urban Fantasy. The reapers perform an important but unrewarding and unprofitable service so they either get jobs or live rough to get by. Decades of being responsible for people's deaths takes an emotional toll on reapers and they cope in various and not necessarily healthy ways.
Similarly, good luck watching another Anti-Hero show after watching Breaking Bad. The show essentially tears apart the whole notion of "good guys do the wrong thing to achieve the right goal." All characters who do the wrong thing, regardless of their intentions, they pay. The main character, Villain Protagonist who manufactures meth to provide for his wife and children, ends up getting disowned by them. His lawyer, Amoral Attorney who covers up his crime and connects him to the criminal underworld, end up having to change identity and live in exile. His brother-in-law DEA, Cowboy Cop who tries to bring him down without calling for backup, ends up getting killed by his criminal associates. His begrudging partner, Hitman with a Heart who puts up with his schemes to pay for his granddaughter's future, ends up getting murdered after their feud gets too hot. Basically, the show's message is this: you Can't Get Away with Nuthin' if you're Breaking Bad. Whatever your ends, if your means ain't legal, it's just going to be All for Nothing.
Firefly's primary raison d'etre is to deconstruct the Space Opera genre. For example, the series opens with an epic battle in which The Alliance soundly defeats the Independent Worlds; The Captain's epic romance never even gets off the ground due to the personality clashes between him and his love interest, and the Raygun Gothic setting is rendered completely moot by the fact that the protagonists are too broke to afford any of the cool technology, and most of that stuff is unreliable anyway. And our heroes survive in this world by stealing, running away and generally being combat pragmatists. One of the early defining moments of the series was when they're about to let a captured enemy go and he gives them a "The Last Thing You Ever See" speech. So they kick him into a jet intake. It also deconstructs the Action Girl, Waif-Fu, and Super Soldier concepts with River, showing just how utterly and completely insane, emotionally-damaged, and traumatized a girl with those capabilities would be.
Malcolm in the Middle could be said to be a deconstruction of all the classic family Sitcom tropes. Instead of being cute and innocent, the kids are evil little troublemakers. Instead of being a stern authority figure the father is a spineless coward. Instead of being a kind loving Matriarch, the mother is strict, arbitrary, unreasonable, and has a volcanic temper. Instead of living in a nice, pristine, two-story suburban house, they live in a small, trashed-out home. (though it does look nice when it's clean) The parents have actual financial trouble, struggling to take care of three to four children while the dad works a dinky office job and the mom, instead of staying at home like most sitcom moms, works in a grocery store. Oh, and of course the lack of a Laugh Track. Malcolm was only following in the footsteps of The Simpsons and Married... with Children, making this more a case of Seinfeld Is Unfunny, as Malcolm definitely took it further.
A dark deconstruction of a typical Dom Com can be found in Titus in which it shows how a dysfunctional family can be messed up in the real world. It also plays around with several other tropes. For example; Titus' and friends' antics lead to bad publicity for their garage, leading to their biggest client demanding his money back, leading to the garage in financial trouble, leading to him drinking to drive Erin away, and so on. In most sitcoms, the guys would just make idiots of themselves publicly, learn A Lesson, then it would be forgotten by the next episode.
The new Battlestar Galactica massively deconstructed the old one, by showing how it "really" would look like if the last people were fleeing from a genocide. By proxy, the show also deconstructed "light" sci-fi like Star Wars.
Arguments have been made that the show is much less of a deconstruction, than it is simply a Darker and Edgier re-imagining; since it fails to address many of the problems of the original. This may be reinforced by the fact that the Cylons have been changed from an irreconcilable alien other, to an Anvilicious screed about mankind being destroyed by their own sins; interspersed with plenty of Fanservice and Fetish Fuel (two words: "dungeon ship"). Further reinforced by the fact that most of the major characters devote epic amounts of time to their personal dysfunctionalities; and seem to be only tangentially concerned with the fact that their entire race has been almost completely wiped out.
It also does away with the Snap Back that fans of Star Trek are familiar with. In Trek, the ship could get shot up with no ill effects next episode. With Galactica, especially following the Battle of New Caprica, you see what effect an epic space battle would have on a ship with no access to a station for repairs.
Many people believe that Glee is a deconstruction of traditional musicals. Unlike other musicals, in Glee most of the musical numbers take place either during a performance or in the character's imaginations, and sometimes both. When a character does try singing their feelings in real life to help their problems, it doesn't work out so well. Other people see Glee as a deconstruction of High School Musical. Whereas High School Musical, being a Disney Channel program for young children, doesn't show many real life high school problems, Glee deals with teen sex, teen pregnancy, homosexuality, homophobia, and drug use. This, however, is unintentional, as the creator of the show, Ryan Murphy, has stated that he's never seen High School Musical.
Glee has largely abandoned its "deconstructing the musical" roots as the seasons have worn on, enthusiastically embracing the idea of bursting into song as a cure for all life's problems.
Pretty Guardian Sailor Moon ends up deconstructing its own source material in increasingly surprising ways as it diverges from the original story, until, by the end, Sailor Moon herself has become the Omnicidal Maniac villain; the senshi's power source, the Silver Crystal, turns out to have really been an Artifact of Doom; and erstwhile villain Queen Beryl is revealed to have actually been trying to save the world, albeit only so she could rule it. The deconstruction arises here as a result of the audience's own genre expectations about the senshi's Power of Friendship and the motivation of the Card Carrying Villains, and how naive and dangerous it'd actually be for the heroines to make such assumptions.
The Ten Commandments miniseries shows the many hard choices (abandoning his family, alienating his adoptive mother, causing his blood brother to do a Face-Heel Turn, killing his most loyal comrade to enforce God's authority) Moses had to make in following God.
Of course, loyalty to God and His cause above all else (sometimes including apparent good sense) is one of the major themes of The Bible from the very beginning.
In a very unique example, as the vast majority of deconstructions are very cynical in nature, The West Wing (a highly idealistic show) could be seen as a deconstruction of the popular conventions of what constitutes political immorality: the Press Secretary spins information not to cover up the government's guilt, but to protect the jobs of heads of state and militaries from the influence of political whims; politicians make unsavory deals with amoral lobbyists and scheming congressmen not for personal gain, but to rescue legislation that would help out thousands of people; the President's speeches and public appearances are carefully scripted not to make him look good, but to prevent confusion and possible panic from people who don't have Masters' in public policy; etc, etc.
24 deconstructed the entire spy thriller genre - even its first season is a far cry from the "torture is everything" mantra in the later seasons. A government agent, who wants nothing more than to spend some downtime reconciling with his wife, gets press-ganged into investigating a potential assassination plot. All of Jack Bauer's co-workers are either revealed as moles or are heavily set up to be one. Jack is willing to defend Los Angeles, no matter how difficult the people (friend and foe alike) around him make it. Everyone that Jack works with either gets killed as a result of his leadership, or hate his guts because he sold them out prior to the events of the series. Jack goes through the entire season looking increasingly haggard and tired, and nods off in the morning while trying to find his family. Jack's wife goes through a Humiliation Conga (including getting kidnapped, being raped, having to flee a safehouse with her daughter and ending up with amnesia) that all amounts to nothing when she gets gutshot by her husband's co-worker and dies after revealing to Jack that she was pregnant. The best thing Jack achieves throughout the series are hollow victories - he's never any better off; even at the end of the series, he has to flee the U.S. after being branded a fugitive.
Law & Order deconstructs both cop shows and courtroom dramas. It doesn't end when the suspect is caught. It's just the beginning of a long litigation process and there's no guarantee the suspect will be found guilty or even that the right person is prosecuted.