From Nobody To Nightmare: Western Animation
- The Fairly OddParents. The episode where Timmy mucks around with a footrace from his Dad's childhood, revealing a Bad Future where he becomes an evil dictator. Also, Mr. Crocker, and how he became evil (he originally had fairy godparents, but a semi-Stable Time Loop resulted in him losing them).
- That said, Mr. Crocker is still a nobody, but he's also come closest, several times, to revealing Timmy's secret, and in The Movie, got himself Powered Armor from a wishing muffin, and it promptly allowed him to Take Over the World until he was defeated.
- In the Fantastic Four: World's Greatest Heroes episode "Puppet Master" the titular villain goes from a frustrated artist to being a legitimate threat to a superhero family.
- Jimmy Neutron once accidentally exposed Libby to a dose of "Megelomanium", which turned her into an Evil Overlord. A fashion-obsessed Evil Overlord.
- Invader Zim: Miss Bitters, Dib and Zim's supernatural monster Sadist Teacher is implied in several episodes to have once been a happy little girl caught in a freak accident. Or a fairy princess who was hit by a bug zapper.
- John Dee, a prison inmate with delusions of grandeur in the Justice League episode "Only a Dream", follows this trope when he becomes Doctor Destiny. Batman, being Genre Savvy, investigates him precisely because he is a nobody.
Green Lantern: Whatever he (Dee) is, he's not in the same league as Grundy and the others. He's a nobody.Batman: Ever read the Odyssey? After Odysseus was caught by the Cyclops, he told it that his name was 'Nobody', so when he poked its eye out and his friends asked who did it all the Cyclops could say was "Nobody."
Dee's wife: John? What are you doing here? Get out!John Dee: Y'know, I never liked that name. It's so... ordinary. Especially for someone with such big things in store. You know, a destiny? Ooh, I like that. DR. Destiny. What do you think?Dee's wife: I think you're crazy!John Dee (transforming into Dr. Destiny): Maybe. Or maybe you're just seeing the real me. And now that I'm a doctor... (turns into a grinning skull) I think I'll perform some surgery.
- The same episode gives us this dialogue, with Dee's literal transformation From Nobody To Nightmare:
- Another Justice League example: David Clinton, an inventor from the Batman Beyond era who appeared in the first season finale of Unlimited. After single-handedly creating a time travel suit, he started building a collection of historical artifacts. At first, he only took things that wouldn't be missed, but after spending six months as the prisoner of a Wild West thug he went flying off the deep end. He used technology from the future to make a League-killing army of the Jokerz and filled Gotham with stolen landmarks from other time periods, polluting history so much that time itself started unraveling.
- Wasp, of Transformers Animated, started as just another Autobot recruit, albeit a bit of an asshole. Then he got framed for espionage and went insane in the stockade, before breaking out years later with vengeance on his mind. And after that, Blackarachnia gets her hands on him and mutates him into the techno-organic Waspinator, which leaves him with uncontrollable electrical powers and makes him even crazier.
- This one's a bit of a meta example, too. There was another, very similar Waspinator in an earlier Transformers series, Beast Wars... But that Waspinator was was The Chew Toy.
- Optimus Prime in most continuities is a heroic example. His origins include being a dock worker, a washout cadet on a repair crew, or a data clerk. The Decepticon uprising forced the humble Orion Pax to reluctantly become the hero Optimus Prime.
- The Transformers Prime version of Megatron was once just a simple Gladiator, in the harsh pits of Kaon. That simple warrior, would eventually plunge a planet into darkness and destruction.
- And before that, like his IDW counterpart, he was a miner, this one a victim of Cybetron's corrupt caste system and a nobody who didn't even have the luxury of a name.
- Otto Octavius in The Spectacular Spider-Man starts out as a meek, put-upon head scientist at OsCorp who spends his days bullied by his Mean Boss Norman Osborn in-between being forced to create supervillains for the mob. One experiment gone wrong later and he's got four mechanical tentacles welded to his spine and all his inhibitions removed, and spends the rest of the series trying his hardest to conquer the world as Dr. Octopus.
- If the series continued, this trope would apply to Harry Osborn.
- Hydro-Man in Spider-Man: The Animated Series. According to him, he was a "nobody" and was expelled from school for causing a lot of trouble. His parents sent him to the navy where he'll straight up. During a voyage, he accidentally fell into ocean where some strange mist from a fissure which "turned [him] from a nothing... into a something!"
- Numerous TAS villains fit. The Hobgoblin was a petty street thug who was granted superpowers by Norman Osborn and turned into a lethally dangerous Psycho for Hire. Venom, aka Eddie Brock, was a failed reporter, before his accquisition of the alien symbiote turned him into one of Spider-Man's worst enemies (his successor, Carnage, averts this, as Kletus Cassady was a Mad Bomber long before he got his symbiote). And then there's Spider-Carnage. Take a badly unhinged kid. Give him Spider-Man's powers. Then, after a long bout of emotional trauma involving clones and an identity crisis, attach the Carnage symbiote to him. Hello Omnicidal Maniac.
- The Kingpin. When Smythe asked about his past, he explained he was the son of a mobster named Willie. Because of his weight, he had no friends and his father considered him weak and useless. During adulthood, Willie tried to help his father in various crimes, with little success. On one robbery, he was forced to take the fall for his father, who then abandoned him. Willie realized he was all alone and he's going take of care himself if he's going to survive. Once out of jail, he learned everything one needs to learn to become a criminal. Over the years, he created the greatest criminal empire on the East Coast with thousand of criminals working for him and now calls himself the Kingpin. As a payback, he had his father executed.
- In Teen Titans Johnny Rancid was the lowest tier criminal to ever appear; just a violent jerk with a motorcycle and a small laser gun. Then he gets the power to rewrite the rules of reality and turns the world into a gothic hellscape.
Raven: Cool... I mean oops.
- Batman Beyond:
- Willie Watt was a nobody who was picked on by the jocks and shunned by all the girls until he was given a visor to control a mini-Kaiju-sized, remote-controlled robot by his overly-aggressive and never satisfied father to fight back with. Willie then donned the visor and essentially went crazy because he was drunk with power and succeeded at getting back at the people who bullied him until Terry/Batman intervened, destroyed the visor and short circuited Willie's brain. Then at the end of the episode with Willie in juvenile, he found out he had gained psychic powers. THEN on a episode in the next season, Willie was released from juvie with a noticeable change in appearance (i.e. buff) and started getting his respect and trying to take Blade, the girl who had rejected him before. Now he was a jacked up, psychotic psychic Somebody.
- Then there's Shriek. He was once Walter Shreeve, a phonologist, sound studier, and engineer. But when he was told his funding would be cut, Derek Powers offered to let him continue if he would kill Bruce Wayne. After his initial battle against Batman, Shriek lost his hearing and began using his powers like any supervillain. And he was one of the more dangerous ones that Terry had to face; at one point, he put a Curse of Babel on the whole city in an effort to get them to hand over Batman to him.
- Ira Billings would come to be known as Spellbinder. He was at first a bitter and underpaid psychologist at Terry's school. To gain some cash, he used his self-made VR technology to get students to steal for him. After being arrested and escaping, he began making even stronger VR simulators giving runaways and unwanted kids a perfect life for a short time in exchange for stealing, knowing they would overdose in time and didn't care. He also got a city-wide manhunt going against Batman by making people think he killed one of his Rogues Gallery in cold blood.
- Batman: The Brave and the Bold: Bullies used to pick on him because he sang in choir, but something very strange occurred when he kept singing higher! The ruffians around him quickly fell into a trance, and it was then, with wicked glee, he made those puppets dance! He's the Music Meister!
- Avatar: The Last Airbender: Long Feng started out as the son of a middle-class merchant. With hard work and careful manipulations, he took over the Dai Li, turned the Earth King into a political figurehead, and became the Big Brother-like ruler of the entire Earth Kingdom. Unfortunetly for him, this came back to bite him when Azula convinced his minions that a ruler that works for power is inferior to a ruler who's born with it.
- Wakfu: Noximilien Coxen was an unassuming watchmaker and a family man. Then he accidentally got his hands on a little something called the Eliacube...
- Wrath-Amon from Conan The Adventurer used to be an ordinary Gila monster. After Ram-Amon used the Black Ring to turn him into a lizard man, Wrath-Amon stole the Black Ring from him and took control of the cult of Set.
- Thanks to the Nanite event in Generator Rex, every living thing on Earth (except White Knight thanks to a near-lethal accident) has the potential to become a horrible monster. The first EVO threat seen in the series was an ordinary guy who spontaneously transformed into a several stories tall Kaiju that only The Hero Rex (a more advanced EVO) can defeat without nuking the area.
- Special mention to Van Kleiss, who was a minor lab technician at the facility that invented the nanites before the event, and is now a Magneto / Orochimaru hybrid leading the largest organized group of malevolent EVOs.
- Alpha from the Heroes United Crossover was a freaking Nanite that eventually became a menace capable of destroying the entire world.
- Mayor Jones of Scooby-Doo! Mystery Incorporated; he started out as a smart kid who got into a good college...then he discovered the treasure hidden in Crystal Cove, setting him down the path that would lead to him being one of the most evil characters in Scooby Doo history. From there, he screw over the original Mystery Incorporated and Professor Pericles by becoming The Freak of Crystal Cove, and then he kidnapped Brad and Judy's son to keep them from getting revenge on him. When Fred Jones Junior found out, he was the angriest I've ever seen the character in any incarnation of the series.
- Also, many villains the gang encounters turn out to be relatively unremarkable or humble folk:
- The Ghost Clown:A circus hypnotist seeking revenge for his imprisonment.
- Captain Cutler:A fisherman posing as his own ghost to steal expensive yachts.
- Space Kook:A farmer trying to take control of his neighbors' land.
- Que Horrifico:An arrogant schoolgirl who thinks she's more fit to run town than adults.
- The Fright Hound:A stay at home mom whose pissed off that her son is an outcast.
- Char Gar Gothakon:A nerdy college student with an unhealthy Cosmic Horror obsession.
- Night Fright: A rejected stage assistant turned into a demonic movie monster.
- Also, many villains the gang encounters turn out to be relatively unremarkable or humble folk:
- Adventure Time has the Ice King, who was just an ordinary antiquarian before The Great Mushroom War but is now one of the series recurring villains.
- The Lich is heavily implied to have once been an ordinary person before the Mushroom Bomb's fallout mutated him into an undead monster.
- The alternate universe of Danny Phantom if you think about it. The title character was an average unpopular kid who suddenly gained super powers and became the local super hero, only to lose his humanity in an attempt to dull the pain of losing his friends and family, and willfully caused The End of the World as We Know It.
- Bolero has an evil, black eyed monkey who starts off as a shadowy figure before eventually becoming a towering man who kills off all the animals, thus halting evolution.
- South Park's Eric Cartman is little more than a potty-mouthed Jerkass Spoiled Brat at the beginning of the series, but becomes a Magnificent Bastard by Season 5, a transformation firmly established by the episode "Scott Tenorman Must Die".
Kyle: Dude, I don't think we should piss Cartman off again from now on.Stan: Yeah, that's a good idea.
- The Legend of Korra's Amon was a young waterbender named Noatok, until his father, a former criminal, forced him and his brother Tarrlok to learn bloodbending. After years of such training, Noatok was fed up with it and ran away from home, convinced that all bending was evil, even implying that he contained self-loathing for being a bender. He would eventually form the Equalists, who sought to rid the world of benders, and tore Republic City apart, socially and politically.
- My Little Pony: Friendship Is Magic: Fluttershy in "Putting Your Hoof Down" is a heroic and downplayed example. She starts off as an Extreme Doormat who was unable to get her pet rabbit, Angel, to eat his vegetables. The next time we see of Fluttershy again after she gets her assertiveness from Iron Will, she became a full-on raging jerkass who lashes out on everyone who tries to push her around again.
- Trixie was a loud egotist whose boasts way exceeded her actual power level, a foil to the immensely powerful but humble Twilight Sparkle. After her home got destroyed and she got laughed at by the whole of Equestria, she acquired a powerful and corrupting artifact, which let her trounce Twilight and enslave Ponyville. She gets better by the end of the episode, once the heroes manage to remove it from Trixie's possession.
- Zoltan and the Gang of Five from Attack of the Killer Tomatoes! were comic relief sidekicks in season one until they mutated into serious threats in the second season and succeeded in taking over the world.
- The toads in Bucky O'Hare and the Toad Wars where initially a race of decadent hedonists, who decided that even running their own society was too much work, so they created an A.I. to run it for them. The A.I. decided it wanted to rule the universe, turned Toad culture into a militaristic nightmare, and went on to try to conquer everything.
- Henchman 21 from The Venture Bros. starts out as an overweight Mauve Shirt who's only valuable asset is his Joker Immunity and a little bit of Genre Savvy-ness. Then his only friend 24 is killed right before his eyes and he undergoes Training from Hell to become Two-Ton 21: a huge, muscle-bound man who can put up a decent fight against (and even earn the respect of) Brock Samson.
Brock Samson: Well, I'll hand it to you, you really can deliver a pretty decent beating.