Lawrence TalbotThe main and title character. He returns to his home in England after his brothers murder. He wishes to look into it, and of course is bitten by a werewolf. He finds out his father was the werewolf who bit him, killed his brother, and his mother.
Sir John TalbotLawrence's father, who had a strained relationship with his son. Lawrence returns home after his brothers death. Turns out he is the werewolf that bit Lawrence, but also killed his brother and mother.
Gwen ConliffeLawrence's love interest. Ben's former fiancce, who wants to know the truth about Ben's death. Overtime they get romantically attached. After finding out Lawrence is a werewolf, she sets out to help him, and ends up killing him.
Inspector Francis AberlineBased on the real life Inspector Fredrick Aberline of the Jack the Ripper murders, Francis is incharge of the investigation of the werewolf murders. He is suspects Lawrence as being the killer, which he technically is. He soon learns the truth and becomes bitten himself.
MalevaA gypsy who warns Lawrence that he is in great danger. After he is bitten, she meets with Gwen who tells her that Lawrence can be killed/saved by someone who loves them.
Dr. HoennegerThe sadistic doctor at the asylum Lawrence is sent to. He publicly tries to prove that Lawrence isn't a werewolf, but it only results in Lawrence transforming in front of everyone.
Ben TalbotLawrence's brother, who is killed in the opening of the film. His death sets the events of the film in motion.