Even before their births these children were chosen by Azazel (The Yellow-Eyed Demon) to serve as his soldiers during the Apocalypse. Special Children refers to chosen individuals to whom Azazel fed his blood on their 6 month birthdays, having snuck into their homes after making a deal with their parents. The result was that the blood awoke/created psychic abilities in them so they could (apparently) lead an army of demons in a war against humanity and God. In "All Hell Breaks Loose, Part One" (S02, Ep21), Azazel tests these children to find who will be the strongest by putting them in an abandoned town called Cold Oak, South Dakota, and manipulating them to fight each other. Azazel led everyone to believe that he wanted a leader for his demon army. However, as it was later revealed, the endgame was bigger, and Azazel chose the children because they were all potential vessels for Lucifer. The strongest one would be chosen to contain Lucifer throughout the apocalypse.
Blessed with Suck: The psychic visions are accompanied by headaches, and it takes Ava and Sam some time to understand what their visions of death really are. Lily accidentally kills her girlfriend by touching her. Scott started to develop migraines, depression, paranoia, and nightmares, as his power manifested.
Summon Magic: Ava learns a very specific form of mind control which she uses on an Acheri demon to help her kill the others at Cold Oak.
Psycho Serum: The demon blood of Azazel, which he fed all of the Special Children at 6 months of age.
Puberty Superpower: These children develop their powers as young adults at 22 years of age.
Superhuman Transfusion/Super Empowerment: They received Azazel's blood to prepare them as infants. Drinking demon blood, as Sam does, also has the ability to increase their powers and is required for Lucifer's vessel.
"It started a little over a year ago? You found you could do things? Things you didnít think were possible? I have visions. I see things before they happen."
After John Winchester is killed in 1973, his girlfriend Mary Campbell agrees to a deal with the Yellow-Eyed Demon. Ten years after that date, the Yellow-Eyed Demon enters the Winchester home on November 2, 1983, to feed his blood to 6 month old Sam, and the demon kills Mary when she interrupts him. The demon blood was used to prepare Sam as a possible vessel for Lucifer. The Yellow-Eyed Demon engineers other tests to determine if Sam is a suitable vessel.
Dark Messiah: Sam starts to believe that he can use his powers to stop Lilith and the Apocalypse, causing him to drink more demon blood and give into his dark side.
Demon Slaying: When Sam's powers are strengthened by drinking demon blood he learns to exorcise a demon under the the tutelage of Ruby. He later becomes able to kill demons with his powers and is resistant to many demon attacks.
Seers: Like Ava, he has visions of the future, often related to death and other Special Children.
Max Miller (Brendan Fletcher)
"When I first found out I could move things it was a gift. My whole life I was helpless but now I had this."
He lives in Saginaw, Michigan, and was trying to save up money to go to school. Max's mother died pinned to the ceiling above his crib when he was 6 months of age. Max was abused by his father, Jim Miller, and his uncle, Roger Miller, as he grew up, while his stepmother, Alice, did nothing to help him. After he gains telekinetic abilities, he takes revenge on those who abused him. Sam and Dean meet him while investigating the death of Jim Miller from carbon monoxide poisoning, which Sam had seen in a vision before it happened. Appears in "Nightmare" (S01, Ep14).
Born in 2006 in Salvation, Iowa, to Monica and Charlie Holt. The Yellow-Eyed Demon enters her nursery on her 6 month birthday, but Sam and Dean save Rosie and Rosie's mother, who like so many Supernatural mothers wears a long white nightgown, from the house fire that erupts. It is unknown whether the Yellow-Eyed Demon had time to feed her his blood and whether she has any special abilities. Appears in "Salvation" (S01, Ep21).
Tykebomb: The Yellow-Eyed Demon has plans for her.
What Happened to the Mouse?: The Winchesters are never shown checking back in with the Holts to see how Rosie is doing, and they never make an effort to track down the other Special Children who may be part of Rosie's generation. These children should start manifesting psychic powers around 2028.
"I mean, you, you learn you've got a twin, you call him up, you go out for a drink, you don't start killing people!"
He was born to 18 year old Holly Beckett on June 30, 1983, in Guthrie, Oklahoma, along with his twin brother. Each of the brothers were adopted by different families, and they did not meet until they were adults. Andy's adoptive mother was killed by the Yellow-Eyed Demon on December 30, 1983. He was able to manipulate people using his power of mind control while living out of his blue van with a barbarian queen painted on the side. Appears in "Simon Said" (S02, Ep05) and "All Hell Breaks Loose, Part One" (S02, Ep21).
Mind Rape: Andy admits to beaming sexually explicit images into another guy's brain at all hours of the day because he thought the guy was a dick. This is played for comedy as the images consist of gay porn.
Nice Guy: A little mischievous but a genuinely good person.
Old Flame: Tracy and he used to date, and have remained friends. He still cares enough about Tracy that he never uses his mind control on her, and Ansem targets Tracy because he thinks there is still a spark between Andy and Tracy.
Pimped Out Van: Andy drives a van with a barbarian queen riding a polar bear on the side and a disco ball, beaded curtain, and tiger painted on velvet in the back.
Plucky Comic Relief: His reaction to developing the ability to project images into people's heads is to torment a Jerk Ass by making him think about gay porn.
"He came to me. In my dream. He said I was special. He told me he's got big plans for me. Wait 'till you see what's in store, Andy, for both of us!"
He is Andy Gallagher's twin and was born to 18 year old Holly Beckett on June 30, 1983, in Guthrie, Oklahoma, but was adopted by the Weems family from upstate while Andy was adopted by a family in Guthrie. There was no house fire when he was 6 month's alone as the Yellow-Eyed Demon was not interrupted, which leads the Winchesters to realize that they could not find all the Special Children by tracking this pattern of house fires. The Yellow-Eyed Demon tells him he has plans for him and also tells him that he has a brother. This leads Ansem to use the fake last name of Weber and take a job in the coffee house where Andy used to work. Appears in "Simon Said" (S02, Ep05).
Cain and Abel: Andy kills Ansem to stop him from killing Dean and Tracey.
Compelling Voice: Like his brother, he can control other people with the sound of his voice.
Crazy Jealous Guy: Ansem tries to kill Tracey because he is concerned about his brother developing other relationships.
Motive Rant: Once Andy confronts Ansem, he admits that he killed Dr. Jennings and their mother because they split up the brothers. Ansem also plans to kill Tracy because he thinks she is trying to come between Andy and him.
"I have this ability. When I touch something, I can electrocute it if I want."
Scott's mother died in a nursery fire when he was 6 months old like Sam, Andy, and Max. This pattern allows Ash to identify Scott as one of the Special Children. Scott, who lives in Lafayette, Indiana, starts to get migraines, and the Yellow-Eyed Demon appears to him in his dreams. He finds he has the ability to kill with electricity through touch. He confesses all of this and the plans the Yellow-Eyed Demon told him about to his psychiatrist, Dr. George Waxler, who does not believe him. Later Ava helps Sam steal Scott's confidential psychiatric medical records. Appears in "Hunted" (S02, Ep10).
"Screw you, buddy. Okay? Because I'm a secretary from Peoria and I'm not part of anything! Okay?"
Ava is a secretary in Peoria, Illinois, who is engaged to marry Brady. She tracks Sam down in Lafayette, Indiana, after she has a vision of Sam dying in an explosion. She disappears after her fiancť is murdered, and Sam and Dean spend a month looking for her without success. Sam finds her 5 months later in Cold Oak, South Dakota. Appears in "Hunted" (S02, Ep10) and "All Hell Breaks Loose, Part One" (S02, Ep21).
Distaff Counterpart: To Sam, sharing his visions and dead fiance. Even when they go off the deep end, how their powers develop mirror each other's—Ava controls demons to kill others, Sam exorcises and kills demons with his brain.
Evil Feels Good: She is forced to start killing to survive Azazel's twisted contest. Eventually, Ava starts to enjoy it.
Face-Heel Turn: She is recruited to the dark side by the Yellow-Eyed Demon.
"Iíve heard enough. Iím better off on my own. FYI, so are you."
Jake lost his mother in a fire when he was six months old. Jake is raised by his grandmother, Debra, in East St. Louis, Illinois, with his sister, Lynn, and younger brother, Danny. He joins the US Army to stay out of trouble and serves as a private in Afghanistan. Jake finds he has super strength when he lifts a tank off Tyrone, a Sergeant who had bullied him. Appears in "All Hell Breaks Loose, Part One" (S02, Ep21).
Anti-Villain: Type III. By the end of "All Hell Breaks Loose, Part 1", he regretfully kills Sam so that he knows at least one of them will survive to kill Azazel, but Azazel then strong-arms Jake into working for him.
Laser-Guided Karma: While Sam's distracted, a seemingly unconscious Jake takes the opportunity to sneak up behind him with a knife and stab him In the Back. Later on, Sam comes back to life and repeatedly shoots Jake in the back.
Love Makes You Evil: Azazel manipulates Jake's love for his family to get him to cooperate: first, he threatens to force-feed Jake's mom and little sister their own intestines if Jake doesn't do as he's told. After that, he tempts Jake into opening the devil's gate by promising that his family will be rich and safe forever in return.
Meaningful Name: "Jake" comes from "Jacob", which means "supplanter", He unexpectedly wins the competition by killing "heavyweight champ" Ava and Sam, the last remaining psychics.
Teach Him Anger: "Loser" revolved around Azazel's attempts to make Jake crack under pressure and turn evil. He originally intended to slaughter Jake's family like he promised to do in the original series, so that Jake would come home from leave to find them Stuffed In The Fridge a la Jessica, but then the Winchesters intervened. Instead Jake's little brother gets shot and killed in front of him by the fellow soldier whose respect he finally earned. It still doesn't work, as Jake remains a decent human being.
The War on Terror: He appears in Cold Oak wearing his ACUs and says he "went to sleep last night in Afghanistan".
Lily Baker (Jessica Harmon)
"I touch people? Their hearts stop. I can barely leave my house. My lifeís not exactly improved. So, screw you, I just wanna go home."
Lily was abandoned by her father, Gray Baker, after he witnessed the Yellow-Eyed Demon feeding his blood to 6 month old Lily and killing Lily's mother. She lives in San Diego, California, and finds out about her powers when she accidentally kills her girlfriend by stopping her heart when she touches her. Appears in "All Hell Breaks Loose, Part One" (S02, Ep21).
Accidental Murder: She inadvertently killed her girlfriend by touching her. Naturally, Lily feels guilty as hell over this.
Disappeared Dad: In the anime, her father, Gray, abandons her after witnessing Azazel feeding her his blood when she was an infant and killing her mother. Gray later teams up with John to save Lily and kill Azazel in "Darkness Calling". Although Lily exorcises the demon and father and daughter reunite, Azazel later returns, possesses Gray, and forces Lily to exorcise him by touch again... this time, killing her father.
Expy: Lily, with her black leather jacket, long hair, and brooding attitude, has many similarities with Rogue, which go beyond their power to kill with a touch.
Genre Blindness: Ignores the other children's warning to stay in the town and stick together, by sneaking away to try to escape through the woods. She is caught by one of Ava's Acheri demons, and hung from a windmill. In Lily's case, it might not be Genre Blindness so much as her desperation leading her to make rash decisions.