It starts in Arizona, then New Jersey, California. Houses burned down to the ground. It's going after families, just like it went after us.
Dean:[to Sam] I mean it. If hunting this demon means you getting yourself killed—then I hope we never find the damn thing.
Written by Sera Gamble and Raelle Tucker.Directed by Robert Singer.Airdate: April 27, 2006.John Winchester has tracked the demon to Salvation, Iowa. He and his sons are determined to kill the demon and save the mother of a six-month-old infant.Sam, Dean, and John make plans to kill the demon who killed Mary Winchester after tracking his movements to Salvation, Iowa, where they think he will target another mother of a six-month old child. Sam has a premonition that gives them a chance to save the Holt family from the same tragedy the Winchesters suffered. But before they have a chance to confront the demon, Meg starts murdering the Winchesters' friends and allies and demands that they turn over the Colt if they want her to stop. John agrees to meet Meg in Lincoln, leaving his sons to deal with the demon using the real Colt. John tries to pass off another antique gun as the Colt, but Meg's associate, Tom, shoots her and reveals that the gun is a fake, and John is captured. Sam and Dean are able to rescue the mother and the infant Rosie Holt, but the Yellow-Eyed Demon escapes.
For this episode = 2 humans (both hunters and close friends of the Winchesters).For the series so far = At least 140 humans; 11 ghosts; 3 vampires; 1 god; 1 rawhead; 1 shapeshifter; 1 shtriga; 1 wendigo.
John: Been waiting a long time for this fight. Now it's here, I'm not gonna be in it. It's up to you boys now. It's your fight, you finish this. You finish what I started. Understand? [he hands Dean the Colt]
Meg: Oh, John, please, mind your blood pressure. So, this is the thing. We're going to keep doing what we're doing. And your friends, anyone who has ever helped you, gave you shelter, anyone you ever loved. They'll all die unless you give us that gun.
Break The Fake: When John hands over the Colt, the other demon shoots it at Meg to prove that it's a fake.
Confessional: Meg pretends to ask for forgiveness from Pastor Jim in the teaser.
Meg: Well, I've lied...a lot. I've stolen. I've lusted. And the other day I met this man—a nice guy, you know? And we had a really good chat...sort of like this. Then I slit his throat and ripped his heart out through his chest. [she blinks and her eyes are suddenly completely black] Does that make me a bad person?
Meg: You hear that? That's the sound of your friend dying. Now let's try this again. We know you have the gun, John, word travels fast. So as far as we're concerned, you just declared war. And this is what war looks like. It has casualties.
Three Bullets Left: Of the 13 bullets made by Samuel Colt, 5 are left in the case when Elkins opens it. One of these is used to kill Luther in "Dead Man's Blood" and another is used in this episode when Sam shoots at the Yellow-Eyed Demon in the nursery.