Butt Monkey: Started down this road in season 2; the other guys suddenly started to give him worse punishments than ever (probably because he's won so many), culminating in the episode where they would pull a challenge out of a lottery barrel at random and they would vote on who should do it. Q got the first one, and while he was doing it, the others decided to make him do every challenge they picked. But, he managed to succeed at all three, and the others made the mistake of taking the punishment together if he managed to unzip a man's fly, resulting in Q testing them about his life (to see who his best friend was) on the edge of a CLIFF.
Face of a Thug: Q is a nice enough guy, but the fact that he looks like a hobo is often poked fun at by the others.
Flanderization: A real-life example, mentioned in the "Anniversary" episode, that the guys started off telling Q he resembled a homeless person, despite being originally clean-shaven, and over time, he actually started to look and act like a homeless person.
Vomit Discretion Shot: In the "Not Safe For Work" punishment, where the sight of Murr posing nude in front of a classroom of art enthusiasts was apparently just too much for Q's stomach to handle, prompting him to drop his lunch in a bucket.
James Stephen "Murr" Murray
"You don't ever want to confise the inferior vena cava with the pulmonary valves, or someone could die."
Bowties Are Cool: Count on Joe to immediately yank the bowtie off and toss it aside.
Butt Monkey: The worst offender in general, and not just during the challenges.
The Charmer: Murr is probably the most sincere when it comes to women.
Cunning Linguist: As reveals the challenge where the guys have to teach foreign languages to students.
A notable example is the punishment for "Human Pinata." Even though both Joe and Murr lose, the guys decide to give the punishment to Murr for no apparent reason, other than because it was funny.
Embarrassing Old Photo: There is a particularly humiliating one of a younger, hairy-chested Murr wearing nothing but his favorite blanket, which once popped up in a live theater in front of a hundred people.
My Friends... and Zoidberg: Murr always seems to be the odd man out (a.e. the episode where he is the only one not wearing a Staten Island T-shirt).
Naked People Are Funny: In "Strip High Five." It happens twice more in the first three episodes of the second half of Season 2, both of them as part of a joke on Sal: pictures of Murr and Q in bed with Sal's sister, and Murr, Joe, and Q hopping around naked in Sal's house.
In the episode "Not Safe For Work", Murr's nudity is so funny that it causes Q to laugh so hard he has to puke in a bucket.
Nice Guy: Out of all four, Murr is the most sensitive when it comes to outright insulting a pretty girl.
Oh Crap: After losing an episode, Murray gets dressed as a pinata and hit with bats by the other Jokers until candy comes out. Unfortunately for Murr, they decide to bring in a ringer: Joe's brother-in-law, a muscular man who wasn't exactly pleased about Murr groping his wife, Joe's sister, during a raunchy political correctness video on a previous episode. Murray is understandably terrified when they hand him a bat and let him go to town.
Up to Eleven: Actually, more like eleven million, in the third season premiere. Murr is the episode's big loser, and he's tricked by the other guys into thinking that his punishment was just another challenge; he thought that they were teaching a skydiving class, but in fact, he would have to actually go skydiving (something he had vehemently refused to do his entire life). His desperate pleading didn't help, and he screamed his way all the way down to the ground.
Omniglot: Murr is apparently this among the four, demonstrating at least a passing familiarity with Armenian, Dutch, and Chinese.
Weirdness Magnet: Murr always seems to encounter the oddest people during the challenges. For example, the guy who had been dating a Macedonian that apparently was a "bit of a slut" and cheated on him with a guy that looked like the "new fat kid dictator of North Korea."
Fearless Fool: Joe is constantly described as by the other guys because he apparently has no fear. Although, there are barriers even he wouldn't reach. For example, Joe will shake his rear end in a woman's face, but couldn't work up the nerve to insert the word "circumcision" into a sentence. A case of Everyone Has Standards, according to Joe himself.
Naked People Are Funny: Narrowly subverted in "Strip High Five", where he narrowly survives humiliation in front of hundreds by ending up in his underwear. Also in "Down in the Dump", when he's wearing only Q's cap in front of his crotch, and during the "Sweat the Small Things" presentation for Sal's home invasion.
And in one of the White Castle challenges, "White Castle regulations is the cap and apron."
Then his rear on Q's computer during an identity theft presentation...
Butt Monkey: Sal has received the most end show punishments. Also, the most recent punishments have hit Sal more personally, such as his fear of cats, the other Jokers dancing around naked in his house, putting him on a boat with his worst nightmare (a heap of trash), and (not a punishment) pictures of Murr and Q in suggestive positions with his sister.
Outside of the show, Sal is mentioned to have had the worst experiences, which include finding a homeless man asleep on his car and getting peed on in a nightclub by a drunk guy.
Why Did It Have to Be Snakes?: Sal is particularly terrified of cats (in contrast to Q, who has two pet cats) in addition to being a germophobe. Of course, the other guys are all too willing to exploit these fears.