- Author's Saving Throw: The writers made a few attempts to rein in their more absurd twists and turns, such as removing Alice's story-breaking superpowers and clone army, and downplaying the ludicrous, virally-induced desertification from the previous film. They also recast Wesker and made him much more similar to his video game version.
- Awesome Music: The opening theme has been known to induce random audience head-bobbing.
- Broken Base: Should have the clone army received more screentime? Some think it was good to remove it, while others would have wanted the plot to use it for anything better than a gigantic Sacrificial Lion.
- He's Just Hiding!: Before the release of Resident Evil: Retribution, fans speculated that Wesker survived the helicopter mini-nuke at the ending of the movie. This is supported by some eagle-eyed viewers noticing a parachute opening in the distance when one of the characters revealed himself to have survived. Wesker's survival was later confirmed by a press release for Retribution.
- Hilarious in Hindsight: The character Crystal Waters is an actress before the zombie apocalypse. The name sounds unintentionally like a nod to Clear Rivers from Final Destination, who is portrayed by Claire Redfield's actress Ali Larter.
- Idiot Plot:
- Half of it by courtesy of Alice. Despite having an army of telekinetic, superhuman, psychically-linked clones, and being herself a trained security operative, Alice somehow decides the best plan to take the Umbrella base in Tokyo is a wild open assault, without any discernible strategy aside from "breakin' in and shootin' em", and not using their powers when they would need them the most. Even worse, when Wesker manages to escape in a VTOL, is revealed that the true Alice had deduced his route and got aboard of the plane; but instead of disabling the plane before Wesker comes, or at least trying to take him down right then and prevent any self-destructive trick (which would be easy to expect given than nuking things up when they get complicated is typical of Umbrella), she waits until he has taken off and blown up all the base, which kills pointlessly all of her clonic sisters, and then holds him dramatically in gunpoint for a pretentious Bond One-Liner. The result? Aside from being now alone and unsupported in a post-apocalyptic world, Alice gets injected with a de-powering serum and ends up trapped in a plane with a guy who has revealed to be as superhuman as she was until that moment.
- Wesker owns the other half, as for all his style and poise, he has his brilliant escape and execution of Alice foiled... because he forgot to put the VTOL in auto-pilot. But it soon gets overshadowed by another feat of stupidity, given that it's later revealed that during the next six months, he had his entire Umbrella crew run away from him out of sheer mismanagement of his need for human flesh. And later, despite having figured Alice's flesh would stabilize his mutation, he stays full Orcus on His Throne at the Arcadia instead of going himself to the prison (where he knows she is thanks to Sinclair being The Mole) to get her now that she is powerless. The best plan he comes up with to bring her to him? Sending an army of zombies which, in the improbable case they overpowered Alice, only would kill or infect her, making a nightmare for Wesker to recover her body if the T-Virus infection had not rendered her inedible for him.
- Even if it is meant to be a Call-Back to an exposition line by the Red Queen in the first film, Wesker's line about how he must ingest fresh DNA can draw laughs for how absurd it is.
- The T-Virus being shaped like actual Ts.
- Star power, bitches!
- Claire backing away from the Executioner looks like she's breakdancing.
- Plot-Driven Breakdown: Played with, When they release Chris he tells them his escape plan, an APC hidden in the locked down garage, however when they unlock the the garage and find the APC... with it's engine apparently sitting right next to it, crosses into slight Idiot Ball territory as they immediately assume that the engine was the APCs, not even bothering to check whether or not it was a spare or backup, for all they knew, the APC was perfectly functional, and they wouldn't have had to take the much more dangerous escape route they found earlier.
- Take That, Scrappy!: Alice gets brought down to normal, ends up on the receiving end of a Curb-Stomp Battle, and has all of her clones wiped out. For many, it was considered to be the best thing that the directors did to try and redeem Extinction. But since Alice is improbably overjoyed by the turn of events, is still the only character to actually do anything, and remains somehow still capable of doing her ludicrous stunts even without superpowers, it's ultimately kind of a moot point.
- They Wasted a Perfectly Good Character: Crystal and Angel's characters don't really get enough lines or prominence, given their performances.
- They Wasted a Perfectly Good Plot: Controversial as the idea could be, the previous film has it to where Alice stumbles upon an entire storage unit of her clones, and the build up to this movie was pretty much based around the fact there was an army of superpowered women taking on Umbrella. However, in the first five minutes of Afterlife, all of them are killed after the base in Tokyo self destructs. A lot of fans looking forward to this were obviously ticked off.
- Took the Bad Film Seriously: Shawn Roberts tried to make Wesker's mannerisms and acting as close to his character's video game counterpart as he could."He's got everything going for himhe's super fast, super strong, has the ability to regenerateit's all the elements from the game. That was one thing we all agreed on from the start: this character has to be for the fans."
YMMV / Resident Evil: Afterlife