- In Memoriam: The game was dedicated to the memories of comic artists, Neal Adams, Tim Sale, Alan Grant, and George Perez. Alongside both Kevin Conroy and Gilbert Gottfried.
- Role Reprise:
- Nolan North reprises Superman from various productions such as Young Justice (2010) and DC Showcase – Batman: Death in the Family and Clayface from Young Justice (2010) as well.
- Diedrich Bader reprises Batman from Batman: The Brave and the Bold and JLA Adventures: Trapped In Time
- Vanessa Marshall reprises Wonder Woman who she first did in Justice League: Crisis on Two Earths
- Josh Keaton reprises the Barry Allen Flash from DC Super Hero Girls
- Tasia Valenza reprises Poison Ivy from Batman: Arkham Series
- Alastair Duncan reprises Alfred Pennyworth who he first did in The Batman
- Cooper Andrews reprises Aquaman from Aquaman: King of Atlantis.
- What Could Have Been: Mister Mxyzptlk was originally going to be voiced by Gilbert Gottfried before he passed away, so Dana Snyder does the role.
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