- Dolled-Up Installment: The game was originally entitled "Virus", and did not star Mario. Wanting to recreate the success of Tetris, Nintendo changed the title and added a labcoat-clad Mario.
- Keep Circulating the Tapes:
- Dr. Mario 64 has only been released on the Nintendo 64 in America, on the iQue Player in China, as one of the games featured in Nintendo Puzzle Collection on the Nintendo GameCube in Japan, and that's it. It is one of the few N64 Mario games to have never been released on the Virtual Console.
- With the Wii Shop Channel closing on January 30th, 2019, it means that the only way to play Dr. Mario Online Rx is to have a Wii where that game has been bought prior to that date.
Trivia / Dr. Mario