- Hilarious in Hindsight:
- In regards to the incident mentioned below, the comic artist Yves Bourgelas once drew a hypothetical joke scenario of what might happen if the Mario Kart series doesn't stop adding Mario and Peach clones, which just so happened to include a baby version of Dr. Mario!
- In WarioWare, Inc.: Mega Microgame$!, Wario runs a modified version of Dr. Mario as an ambitious Back-Alley Doctor. Come Dr. Mario World, this ambition becomes a reality after 16 years!
- Just Here for Godzilla: Many fans tend to know and play Dr. Mario 64 because it has characters from the Wario Land series (specficially Wario Land 3) involved in the game's plot, which is a rarity for the Mario franchise.
- Memetic Mutation:
- This remix of the theme song, found in Super Smash Bros. Melee, is very popular in Japanese MAD videos.
- Joking about Dr. Mario's credentials is commonplace. This went into overdrive with Hilarious in Hindsight come Dr. Mario World, where we not only get characters such as Yoshi, Peach and Toadette becoming doctors with dubious credentials, but Bowser, his son Bowser Jr., the Koopalings and Wario and Waluigi as well. And then we also have five baby doctors. Yes, we have Dr. Baby Mario, all the way through to Dr. Baby Rosalina, even adding in the forgotten Baby Wario as a Doctor too!, all complete with pacifiers, baggy coats and other accessories.
- The mere existence (and plain ridiculousness) of Dr. Goomba Tower, who is basically three Goombas wearing a baggy coat, got people to sarcastically request his inclusion in the Mario Kart and Super Smash Bros. games.
- Taken Up to Eleven with a Dr. Dolphin. Yes, the dolphins that only appeared in Super Mario World and then a handful of Mario Party games is also a doctor.
- The sheer amount of variant characters in the game has led some to ask when the game will be getting characters like "Dr. Baby Metal Fire Vampire Wario".
- Nightmare Fuel: As usual, here we have the Game Over music. It starts off in a chilling way and then it merely gets worse. This is not helped by the viruses laughing at the player and Dr. Mario shrugging his shoulders while looking sad.
- Polished Port: The Game Boy version of the original game. Literally the only thing that puts it below the other versions is the lack of color, which makes it slightly more difficult to discern between the different virus & mega-vitamin types under certain lighting conditions. The Game Boy has a monochrome screen, so instead of using colors to denote the Viruses & Mega-Vitamins, it uses 3 different shade formats. Yellow becomes white, red becomes black, and blue becomes dithered gray. When playing the game with a back-light, or on an emulator, telling them apart is easy. It's not easy however when you're playing the game on the original Game Boy in a well lit environment, where the shades can get easy to mix up. Barring this, the Game Boy Version is faithful to the NES original and has solid gameplay.
- Stock Parody Jokes: Parodies where Mario is a shady Back-Alley Doctor. The Dr. Mario games imply that Mario is closer to a research chemist. Shallow Parodies have him prescribing pills to patients, but all we see in the actual games are him performing experiments on the effects of vitamins on virus cultures.
- Suspiciously Similar Song: "Fever" for "Lady Madonna" by The Beatles, "Chill" for "St. Thomas" by Sonny Rollins. As well as the main title theme for "Sherry" by Frankie Valli and the Four Seasons.
- Ugly Cute: For a bunch of little disease-spreading creeps who laugh at the player when they lose, the viruses are actually considered cute by fans.
- Unexpected Character: Dr. Mario World is one hell of a character-clone magnet, more so than Mario Kart ever was, just due to the absurdity of the character decisions, as well as just how many clones there are of Mario, Luigi, Peach, Daisy and Rosalina there are. The game not only includes Fire Mario and Fire Peach as characters, but also the baby versions of those five too (one could argue this common practice at this point). And then the game includes characters that are normally enemies in the mainline games, such as Dry Bowser, Dr. Goomba Tower (who barely qualifies as a doctor since it's just three Goombas blatantly wearing a baggy coat), side characters from other games like Nabbit (who hasn't been playable outside of New Super Luigi U), Dr. Dolphin (representing the ally species of Dolphins that first appeared in Super Mario World, and then only appeared sporadically in spin-off games), and even characters that were once forgotten about, such as the bizarre inclusion of Baby Wario, who has been M.I.A. since his debut in 2006's Yoshi's Island DS. At this point, the game has firmly established just how crazy it was willing to go for its character roster.
YMMV / Dr. Mario