- Memetic Mutation:
- This remix of the theme song, found in Super Smash Bros. Melee, is very popular in Japanese MAD videos.
- Joking about Dr. Mario's credentials is commonplace. This went into overdrive Hilarious in Hindsight come Dr. Mario World, where we not only get characters such as Yoshi, Peach and Toadette becoming doctors, but Bowser, his son Bowser Jr., and even the Koopalings as well. And then data for four babies was discovered. Yes, we have Dr. Baby Daisy, complete with pacifier.
- Nightmare Fuel: As usual, here we have the Game Over music. It starts off in a chilling way and then it merely gets worse. This is not helped by the viruses laughing at the player and Dr. Mario shrugging his shoulders while looking sad.
- Polished Port: The Game Boy version of the original game. Literally the only thing that puts it below the other versions is the lack of color, which makes it slightly more difficult to discern between the different virus & mega-vitamin types under certain lighting conditions. The Game Boy has a monochrome screen, so instead of using colors to denote the Viruses & Mega-Vitamins, it uses 3 different shade formats. Yellow becomes white, red becomes black, and blue becomes dithered gray. When playing the game with a back-light, or on an emulator, telling them apart is easy. It's not easy however when you're playing the game on the original Game Boy in a well lit environment, where the shades can get easy to mix up. Barring this, the Game Boy Version is faithful to the NES original and has solid gameplay.
- Suspiciously Similar Song: "Fever" for "Lady Madonna" by The Beatles. And the main title theme for "Sherry" by Frankie Valli and the Four Seasons.
- Ugly Cute: For a bunch of little disease-spreading creeps who laugh at the player when they lose, the viruses are actually considered cute by fans.
YMMV / Dr. Mario