- Actor Allusion: Sigourney Weaver's tourist character gets on Mrs. Tishall's nerves. In Real Life, Selina Cadell (Mrs. Tishell) and Weaver are best friends.
- The Danza: Martin Clunes as Dr Martin Ellingham. Further variant in that the character's surname is an anagram of series creator Dominic Minghella.
- Follow the Leader:
- Location Doubling: The fictional Portwenn is played by Cornish village Port Isaac. This gets a Shout-Out in the Spanish version, "Doctor Mateo". The fictional town in which the Spanish version is played, San Martín del Sella (actually Lastres), is said to be a sister town to Portwenn.
- McLeaned: Aunt Joan was killed off after Stephanie Cole chose not to return for Series 5. The character was a fixture in the setting and Martin's life, so killing her off was probably the most plausible explanation for her sudden disappearance.
- Playing Against Type: Ian McNeice usually plays characters who are, if not posh, at least of a high status in their sphere. Here, he plays the decidedly working-class Bert Large.
Trivia / Doc Martin