- Acclaimed Flop: Upon the game's release, it became an instant hit among players, who praised it for its involved plot and characterization, high-quality music, solid conclusion to the plot of the Mysterious saga, and gameplay that fixed many of the severe issues that had plagued Sophie and Firis. Unfortunately, it was too late; said two games had caused a massive drop in audience interest, and despite an involved 20th anniversary campaign from Gust that advertised Lydie & Suelle as different from past entries, the game's actual sales were atrocious, with its first-week Japanese sales being the worst in the franchise since Mana Khemia 2. The sales in Japan were so bad to the point that the licensor, Koei Tecmo, opted not to dub the series. However, as Sleeper Hit mentions, the game did not remain a flop for long.
- Milestone Celebration: The game was advertised as commemorating Atelier's 20th anniversary, although in practice it doesn't do anything special to observe it and simply serves as the final Mysterious entry as it would have had it been released any other year.
- No Dub for You: This is the first main line game to be localized without an English-language voice dub, breaking the standard that had been in place since Atelier Iris thirteen years prior. Some speculated that it's mostly because this title flopped in Japan and the low sales in Japan probably wouldn't justify a dubbed release (see Acclaimed Flop). However, with the decent sales after 4 months (see Sleeper Hit), some questioned why Koei Tecmo opted not to dub this installment. It was later confirmed by a PR manager from Koei Tecmo that the American fanbase preference of the Japanese voices is the reason why the stopped dubbing the games altogether.
- Sleeper Hit: After a first week of poor sales, the game was written off as an Acclaimed Flop. However, thanks to good word of mouth, Lydie & Suelle eventually tracked to 180,000+ units sold in Japan and Asia after 4 months. This meant that Lydie & Suelle eventually became the most successful entry of the Mysterious saga, the second most successful Game game ever if enhanced editions and remakes aren't included, and the fifth most successful Gust game ever if they are included.
Trivia / Atelier Lydie & Suelle: The Alchemists and the Mysterious Paintings