- Chinese episode title: "奔跑吧超人兄弟" (Benpao Ba Chaoren Xiongdi)English translation: "Run, Superman Brothers"
The Supermen must find their way around when Big M. traps them in a video game.
"Run, Superman Brothers" contains the following tropes:
- Balloon Belly: Around the beginning of the episode, Happy S. has an inflated stomach from eating so much.
- High-Pressure Emotion: After Smart S. defeats a monster using Sweet S.'s lunch, a not-very-amused Sweet S. has steam coming out of her head.
- Lethal Lava Land: The final level of the game is filled with lots of lava and features a volcano monster for a boss.
- Level Ate: The first level of the game is a world filled with big candy suckers and similar sweet treats.
- Shout-Out: Smart S. feeds the monster in the first level Sweet S.'s food using a Pokeball, even saying "I choose you!" as he does so.
- Slippy-Slidey Ice World: The second level of the game is a cold, icy world.
- Wheel o' Feet: When Sweet S. chases Smart S. over him having fed her food to a monster, both characters' legs are drawn as spinning swirling shapes.
- Win to Exit: The Supermen have to win the game to escape it; otherwise, they'll be trapped forever.