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  • Stan's one-eyed father provides a briefly shocking moment when Steve wakes him in the night and he turns toward the camera revealing he airs out his socket at night because if it gets damp it grows mushrooms. Seeing what is normally covered by his patch out of the blue is momentarily startling. He also stores spices in the empty socket, and can also drink through it.
  • "Roger Codger" had Stan pull Roger's eye out with a fork when he thought that Roger was dead, and in "Frannie 911" during the montage of Roger's health deteriorating as he's forced to be nice, his right eye comes out of its socket after he irons Stan's vest. Apparently, Roger didn't suffer any visual impairments from those two incidents.
  • In "A Smith in the Hand", an Anvilicious video on the dangers of masturbation begins with a boy coming home from school, entering the bathroom with a copy of National Geographic with an African tribeswoman on the cover, and shortly after coming out, his eyes melt and his palms become covered in hair as he lets out a Big "NO!".
  • In "When a Stan Loves a Woman", when Stan and Joanna order fondue at a restaurant and refuse to wait for it to cool, Stan claims that he's going to stick his hand in it and Joanna tries to one-up him by dipping her contact lens in it and putting it back in. Cut to them outside the Smith residence with Stan in a cast and Joanna wearing an eyepatch.
  • In "A Ward Show", Roger's friend Freddy can produce a high-pitched screech that causes people within earshot to have a single eye come out of its socket.
  • In "Kloger", Hayley gets a case of pinkeye that starts off in her right eye before spreading to her left. It gets progressively worse until near the end of the episode her eyes swell shut.
  • In "The Mural of the Story", Stan attempts to reconstruct Hayley's face in her sleep after blaming her for his failed attempt to restore a mural. He starts by removing her eyes from their sockets with a chisel, in a very Nausea Fuel-heavy scene.
  • In "The Ballad of Old Ulysses", as Stan and Steve battle the titular sea monster while powered up by a special energy drink, Steve plants an anchor in its eye.
  • Roger's subplot in "Stan & Francine & Connie & Ted" begins with him going blind after looking directly at a solar eclipse, thinking that his Transitions lenses were enough protection.
  • In "Jeff and the Dank-Ass Weed Factory", when Stan reveals that he was faking being high, he demonstrates that he jabbed himself in the eyes to turn them pink, accompanied by a cartoonish sound.
  • In "Businessly Brunette", Roger has Hayley punch through a wooden board to build her confidence, and she accidentally punches his eye into its socket. He pops it out, causing it to hang out by its nerve, then he yo-yos it back in.
  • Near the end of "Dammmm, Stan!", Francine uses her fly fishing pole to rip out Cleonard's left eye, then his right, then his two "Pan's Labyrinth eyes" in his hands.
  • In "Comb Over: A Hair Piece", after Stan gets a hair transplant, Roger uses an astringent on it and gets a drop in Stan's left eye, leaving him blinded in it until the next scene.
  • Hayley and Jeff's subplot in "Dressed Down" is them attempting to start their own cruelty-free chicken farm, only to find the chickens impossible to control. When the chickens take over their room, Jeff gets his eye near the bottom of the door and one of the chickens kicks him in it. He's wearing an eyepatch in a later scene.
  • In "American Dad Graffito", as part of his attempts to reinvigorate interest in The '50s, Stan throws a chunk of asbestos in a woman's face, leaving one of her eyes irritated. At the very end of the episode, after jumping out of an out-of-control '50s hot rod before it crashed, Stan gets brain damage and one of his eyes is visibly dilated.
  • In Roger's B-plot in "A Song of Knives and Fire", as the finale of his knife-throwing act, he tells his audience that he put knives under their seats and challenges them to nail him with them. He gets hit with several dozen knives, ultimately ending with him taking one to his right eye.

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