These are what we call the 'YMMV items.' Things that some people find in this work. We call them 'your mileage might vary' because not everyone sees these things in the same way. This starts discussions in the trope lists, a thing we don't want. Please use the discussion page if you'd like to discuss any of these items.
Accidental Innuendo: The Molester sidequest. No worries, you're just playing Okami's version of Whack-A-Mole.
Big Lipped Alligator Moment: Quite a few. Kaguya is probably the most notable example, but her plot does make some sense at the very end of the game. Still very little albeit, but some.
"Kushi's Ride" is comparable to The Legend of Zelda: Twilight Princess' "Midna's Lament". Both songs are played during urgent events, but while the latter is a melancholy solo piano arrangement of a character's theme, the other is more orchestrated and bass heavy.
Game Breaker: Vengeance Slips render Amaterasu invulnerable to any combat damage, and they last a while too. Add this to that you can buy them at a price that's oddly low by the end of the game and you can hold 99 of them, and nothing can touch you.
The String of Beads makes the game almost too easy, but you really have to Earn Your Fun by finding all 100 stray beads is a pain in the ass. Not only is it the second most powerful weapon available (with x10 damage), but you get buffs of unlimited health and unlimited ink to boot.
Hilarious in Hindsight: Fish get really bad treatment in this game, being food and the objective of a mini game. As it turns out, Yami, the final boss, is a evil fish inside of an evil mech.
I Am Not Shazam: A lot of fan works, especially videos, seem to assume the lead character's name is "Ōkami". It is part of her name (the caption when she's introduced reads "Okami Amaterasu"). It's just that Amaterasu is the most important part of the name. As noted under Punny Name, Ōkami can also mean "great god," rendering it as "Great god Amaterasu."
Moral Event Horizon: Ninetails crosses it long before we ever meet him, but we don't find out until he murders Queen Himiko that he also killed Rao, assumed her form, and was trying to get Amaterasu killed the whole time.
Most Wonderful Sound: The little chord of the Celestial Brush can be very comforting, especially in stressful areas.
Both the Water Dragon and the Sunken Ship provide this during the Sei-an Arc. There's a particularly cruel instance of this early on in there. When our heroes find a lot of treasure chests just lying around, Issun comments on it. The Genre Savvy player naturally assumes at least one is a Mimic, and checks using the power slash. The mimics are the ones at the back and sides, by which point you might've already started checking them in the usual fashion. The worst part about the ship is the ghosts of the two previous bosses that come out of nowhere, that nobody else reacts to, and come straight up and make faces at the player. They keep moving even if you go to use your brush to get rid of them, which you can't.
Mr. and Mrs. Cutter.
That giant green seaweed hand from the deep. At 10 PM. * sigh* And things were going so well.
Before the Water Dragon, there's Blight. At least with the Dragon level you're not inside a human.
Those demon locks.
Those goddamned giant spiders that literally go down on you without a warning.
Some Anvils Need to Be Dropped: The game is approximately as subtle as a shotgun in the way it presents its lessons, but they're lessons that need learning. Two of the biggest ones are that people shouldn't be selfish with their prayers, and te lhey also shouldn't rely on the gods to fix everything for them. You can usually count on Issun to deliver one of these.
Also the lesson that you shouldn't shirk your duties, because you could have a great adventure in doing so. This one is hammered in by Issun as well.
The Gale Shrine ghost who mentions that he is Fuse's husband before departing. Queen Himiko 's death. Shiranui dying in front of Amaterasu. Amaterasu going home.
Even Tobi gets one when he dies, despite literally being a scrap of paper. At least you have something to blow your nose on.
That One Boss: Okikurumi, despite not even being an enemy, let alone an important boss, is surprisingly hard the first time you fight him. Especially when he starts using his ice clones. Even more surprising since you meet him not long after defeating Kyūbi and make your first steps in the northern region. Talk about a welcome!
A common (and easy, if semi-cheaterish) strategy for Blockheads is to film the screen with a camera or phone, then play it back as you use the Celestial Brush.
You can also tape a piece of cellophane over the screen and use a marker.
Also pausing with home button every two dots and writing down on paper.
Black Devil Gates. Not only are the enemies in them tougher than usual, but they come at the player in much larger hordes, spawn more often, and can deliver more damage per hit. On top of that, there are ten of them one after the other, and each gate throws progressively harder enemies at the player. On top of that, the player won't get the stray bead if he or she leaves the cave before completing all ten gates. And on top of that, the later ones include bosses that appear in pairs or even trios, each one harder to beat than they were originally, and none of them caring about Mook Chivalry, preferring instead to rush you and hit you with everything they got. They are almost certainly the hardest fights in the entire game; even the final boss seems like a breeze by comparison.
Catching the Marlin, winning the race to get the Gimmick Gear, or the race against Kai in Yoshpet to earn a Stray Bead will also cause you to throw your controller.
That Nut Ball moving in Agata Forest. Here's the situation: You have to push a spherical object up a hill so Sleepy Bear will jump on it and give you some Praise. The ball will slip to the side after you push it a few steps, and then you have to chase it before it rolls all the way back down the hill. If you so much as bump it the wrong direction, it will FLY back down the hill, and you'll have to start all over again. The camera will constantly turn as you're running back and forth trying to control this damn ball, and you will inevitably lose sight of it at some point. By the time you turn the camera to see it again, it's already rolled back down. If you manage to get it ALMOST to the top, you have to navigate it across a narrow path with a cliff on one side and a drop off on the other. Bump it off the drop, you're back to square one. Also, the cliff is a low overhang, so the camera suddenly whips around and does an awkward close up just as you're passing the most difficult part. And to get all the praise from ol' Sleepy Bear, you have to do this THREE TIMES, with a cabbage, a giant walnut, and a beehive.
Every side quest that involves pushing a ball. That kid in Wep'keer never seems to find the snowball big enough.
Trying to draw the shapes for Mr. Chic. You spend literally dozens of tries getting it to accept the right shape, but then it accepts something that looks just like the others. It's even worse on the Wii when you have to draw the star twice. You'd think twice in a row would make it easier, but the first time is so hard, what with the finicky controls, just trying to draw five connecting straight lines, by the second time, you're too tired and frustrated to get it right.
That stupid Molester "Whack-a-Mole" game in Taka Pass.
Yoshpet isn't called the Forest of Confusion for nothing. In the beginning of the dungeon, there are thorny holes you have to jump through. Sometimes, they move around, so it's a bit hard to get through without taking damage. There are corrupted trees chucking poisonous pollen at you, and if you come too close to them, they'll just whack you with their trunk instead of taking the time to throw pollen at you. Some levels require you to jump across patches of ice. If that wasn't already annoying, there's acid water in between the little islands, so if you fall off, you have to start over. Then, icicles start falling from the sky, and in a couple of areas, you have to dodge gigantic snowballs. And you have a time limit.
If it's your first playthrough of Oni Island, it might take a bit to figure things out.