Ash from Evil Dead appears again, this time keeping Spider-Man from seeing Mary Jane's play.
Joel McHale as the bank teller, and Donnell Rawlings (Ashy Larry) as the witness of the pizza "heist" (the source of this film's Memetic Mutation, by the way). Apparently, Dave Chappelle himself was supposed to be the guy in the elevator, but for whatever reason he was replaced by Hal Sparks of Queer as Folk/Best Week Ever fame.
Joel would reference his cameo three years later in an episode of The Soup with a spoof trailer of Spider-Man 3, where his bank-teller character becomes a Magnificent Bastard.
Celebrity Voice Actor: The game has the voices of Tobey Maguire (Spider-Man), Kirsten Dunst (Mary Jane), Alfred Molina (Dr. Octopus), and Bruce Campbell as the Narrator. Additionally, whilst some movie characters are not voiced by their film counterparts, they are played by notable character actors such as Mindy Sterling (Aunt May) and Susan Egan (Rosalie Octavius).
Michael Beattie reprises his role from the first game as the Shocker.
What Could Have Been: The 2003 trailer sported a more cel-shaded style, and showcased the Lizard, who never made it into the game (though there were reptile men of sorts in the game, though only in an unlockable bonus mode).