Trivia for the film:
- What Could Have Been:
- After an injury during filming Seabiscuit, Maguire (Spider-Man) was almost replaced by Jake Gyllenhaal. Both would later co-star in 2009's Brothers.
- Doc Ock aside, previous drafts included the Lizard and Black Cat villains. Another draft featured a younger Octavius who created the spider that bit Peter. In the end, all ideas were scrapped.
Trivia for the game:
- Celebrity Voice Actor: The game has the voices of Tobey Maguire (Spider-Man), Kirsten Dunst (Mary Jane), Alfred Molina (Dr. Octopus), and Bruce Campbell as the Narrator. Additionally, whilst some movie characters are not voiced by their film counterparts, they are played by notable character actors such as Mindy Sterling (Aunt May)
- What Could Have Been: The 2003 trailer sported a more cel-shaded style, and showcased the Lizard, who never made it into the game (though there were lizard men of sorts in the game, though only in the unlockable bonus fight arena mode). One of the hint markers makes a reference to this; "Everyone knows that lizards only live in sewers anyway."