One of the better examples is the wedding of Mary Jane and Peter Parker, done because Stan Lee wanted to marry them in the daily newspaper comic strip. Of course, that didn't stop Tom Brevoort from claiming that One More Day was actually a "fix" to this form of "meddling".
What Could Have Been: Stan Lee has gone on record as saying if Gwen Stacy hadn't been killed off, most like she would've ended up married to Peter. Some stories, like House Of M, have toyed with this idea.
Joe Quesada wanted to bring Gwen back from the dead in Brand New Day but it was decided against.
Young Allies offered Anya Corazon a potential chance to shine. It had a cast with the potential to create a very interesting character dynamics, and which Anya shone through as the most down to Earth, and easiest to relate to character. But it was killed by poorly written out enemies, an uninteresting and almost generic story arc, and a refusal by Sean McKeever to give the team any sort of cohesion in spite of their common purpose and motivations.
It really seemed the team was finally coming together by the 5th issue or so, but by then the series was canceled. The Young Allies have been popping up here and there however, most recently in Spider-Island.
Word of Gay: Mysterio, in some of the spin-off novels.
Jennifer Hale, who was in both TAS and Unlimited, reprises her roles in both series as, respectively, Black Cat and Mary Jane in the first game, then in the second game, voices Rogue
Literally almost everyone else in the two games were voiced by either Daran Norris (Venom, Mysterio, Scorpion, The Punisher, The Human Torch and Captain America in the first game and Shocker, Sandman, and Professor X in the second) or Dee Bradley Baker (Carnage, Rhino, J. Jonah Jameson, and Daredevil in the first game; Electro, Hammerhead, and Beast in the second; and the Lizard in both games, with his alter-ego, Curt Connors, in the second one. Baker would reprise the role of Connors/Lizard in The Spectacular Spider-Man).
In the Japanese version, Shinichiro Miki is Spidey and Rei Sakuma is Black Cat (and also can be considered as an Actor Allusion, since she voices Kuro, a literal black cat in the Super Robot Wars games, not to mention Shampoo who can transform into a cat.
It's a good thing that Peter never had his head cut off in the middle of the desert by drug crazed journalists, otherwise he'd never be able to stop Special Agent Smecker from killing Claudia, who apparently finally grew up.
Looks like Randy Savage has been trying his hand at the independent circuits as Bonesaw. Wonder how it's treating him?