As a possible subversion, Ping (A robot, and therefore possibly capable of a literal BSOD) seems to be having one after nearly accidentally hurting her friend here. It's commented upon by Piro here.
In City of Reality Todo gets this after seeing AV gets shot in the Do You Believe In Magic storyline.
In Erfworld, when Jillian is unable to rationalize her way around a conflict between Wanda's influence and her loyalty to Ansom, she briefly collapses. She recovers and charges into battle, resulting in a major victory for Ansom's side. This stuns Wanda into a considerably more severe BSOD of her own.
Later, it turns out that this may simply be backlash from the breaking of Wanda's suggestion spell.
Parodied in Exterminatus Now! After hearing that an old friend of his is behind an assassination attempt on his boss, Eastwood goes into a trance and spends a few minutes repeating his name. His teammates take the opportunity to steal his wallet.
Black Mage later fakes one when he accidently killed White Mage. She got better.
When White Mage realizes that all of her well-intended acts inevitably lead to ruin, she experiences a BSOD that actually turns her evil for a while. Of course, because it's White Mage, it doesn't work, and she quickly reverts back.
That the best you can think of? What about Faye after her dad died?
I do believe that Marten sorta suffered from one when he and Dora broke up.
Pintsize comically suffers from them on occasion.
Marten's friend Steve (I think it's Steve) does this...only though in his case he ends up going on an adventure, becoming a spy and all that.....though I'm not sure if it happened, as it may have been a case of Put on a Bus.
Although having his first period might have contributed to that emotional roller coaster.
Ash gets it again when Vashiel tells him that Rumisiel won't be able to return to Heaven for another 72 years, meaning he won't be able to correct his misfile mistake until then. Considering the average human lifespan, Ash realizes that he will have to stay the way he is for the rest of his life. It takes a visit from Emily to snap him out of it.
In Sluggy Freelance, Torg goes through a mild one of these after an Alternate Universe version of Zoe he'd been dating dies, and immediately jumps to Roaring Rampage Of Revenge mode. He never completely stops being his goofy self after the ordeal and returning to his home dimension, but he is a lot angrier and mopier for a while, especially around Zoe.
Lilah's miscarriage in Ctrl+Alt+Del forces Ethan to go into Heroic BSOD mode. He spends the next several comics wandering around in a zombie-like state (the lack of sleep might have contributed to that), and was seen trying to get a soda out of a vending machine until moments later, when he says he's not even thirsty and that seeing Lilah inconsolable was far too much for him.
The innocent titular character in Rice Boy has to travel the harsh wilderness, be dosed with liquid despair, learn cosmic secrets at the cost of other people's lives, see a hundred clones of himself spawned and cut down, and know that he must save the world and die. Suffering a Heroic BSOD he throws himself off a cliff ... into the next stage of his quest.
Vaarsuvius as well, as the result of what the elf perceives as a great failure back in Azure City and in everything that has happened since, to the point where everything the elf does has the underlying tone of being horrifically, terribly afraid of continuing to fail in new and horrifying ways.
Elan goes through this after he realizes his father Tarquin is evil, and not in a Noble Demon sort of way. It gets worse when he tries to kill him, only for his father to tell him that he'll win either way: If he wins then he wins and if he loses then he'll at least he'll go down in legend and that he'll at least have lived a great life.
In Fletcher Apts, Doug often blanks out and mentally reboots when he sees a girl flash her breasts. Like in this strip, he forgot the answer to the homework problem he was talking about, and in this strip his brain literally flashes a BSOD, causing Doug to forget his lesson and possibly the entire week beforehand.
Lampshaded in Shortpacked!! When Ethan realizes how gratuitously evil he's being, his shock and horror causes the strip itself to "crash"—complete with BSOD.
As an added bonus, that entire chapter was namedHeroic BSOD
In "4our-Calendar Cafe", Cambel and Sara both had a BSOD moment when they heard of Michael Jackson's death in this strip. Although clearly not part of the cannon, the author himself said "pretty much all of us entered a state of Blue Screen of Death when we heard about the news".
Kate of Instant Classic suffers one after learning that Orson Welles (whom she idolizes) voice acted in an anime (a genre that she regards as the lowest, least dignified form of filmmaking).
In Homestuck, John is given the command "mental breakdown" after discovering Fruit Gushers are made by Betty Crocker. In actuality, this trope is brilliantly and hilariously subverted. THIS IS STUPID
However, this is played very straight immediately before the above example, where John's discovery that his dad is just a boring businessman and isn't really into "harlequins" at all is enough to send him into the fetal postion.
Surprisingly, Karkat is by far the most prone to this trope:
And another very shortly thereafter when he finds out that Gamzee flippedthefuckout. Much later on, it's implied in a conversation with John that he's only just recovered from another following encountering post-flipout Gamzee in person and presumably having to kill him. (Although it's revealed Karkat was able to calm him down rather than kill him)
And another, less serious one when he freaks out about possible troll-human relationships that might develop during the three years on the asteroid, complete with a Call Back to the first example in this list.
Dave has a pretty nasty nervous breakdown after finding his Bro dead, impaled on his own katana. He tries to play it off for a little while, but after failing to retrieve the sword from the body, his cool shatters in the middle of his conversation with Terezi. Combined with the stress of managing stable time loops and watching many doomed timeline selves die horribly, Dave remains something of a shell-shocked mess for the rest of Act 5. He seems to have gotten some of his mojo back during the 3-year meteor journey but is still dealing with the lingering trauma in Act 6.
WV gets one after the demolition of his rebellion. Complete with Mood Whiplash, I might add.
Yumiko experienced one in And Shine Heaven Now when she finds out not only isn't she the original personality, but she has eleven split personalities in total. She then suffers a second one when Heinkel releases them, while the personalities sort themselves out.
Dejoru in Juathuur, after being abandoned by everyone and seeing Mijuu die in front of him.
Peanut of Housepets! is prone to having these when confronted with his socially unacceptable attraction to cats, most recently when his best friend and adopted sister Grape revealed that she knew about his secret, long-time crush on her.
Lloyd from Murphy's Law experiences this after he discovers that the dragon that he had been fighting, wasn't evil.
Rikk had one in Fans! when a fellow Aegis member Hilda committed suicide right in front of him. Shortly after the suicide, Rikk learned that "Hilda" was an artificially constructed homunculus created by the Aegis' enemies, and the "suicide" was staged to create just that response in Rikk.
Not the most heroic example, but the Nameless Grad Student of Piled Higher and Deeper experiences one when his experimental results turn up lacking. It's even lampshaded by his advisor: .
In Penny Arcade, Tycho goes into one when he sees an ad for a place called "Gamez N Flix", which made the always elegant Tycho go mad.
Antimony, in chapter 31 of Gunnerkrigg Court after being told that she was the reason for her mother's death, reels back in shock and proceeds to run out of the Court and into the Forest, setting off the alarm, and creating a huge firewall of death to prevent anyone following her.
It helps that the art is also bizarrely warped to represent her crazed state of mind
Gilgamesh Wulfenbach suffers one of these when he thinks that Agatha's dead. Agatha later has one of her own when Lars dies, but hers involves a calliope and an attack carousel. Given the Grayand Black Morality of the characters, the degree of Heroic in Heroic BSOD may vary.
Not the first time Germany BSODs. He did it before when, after he begs the Scandinavian countries not to fly his flag around cause it makes his people prideful, it's pointed out that his shirt has the flag on it too.
It's Walky!!: During the strip's climax, Linda Walkerton was taken out of commission by Her preserved, pre-resurrection corpse and the information that she'd died, been brought back, and manipulated into doing the will of Dargon Chesterfield and his compatriots, which turned her understanding of the most important moment in her life and the aftermath thereof on its head.
The titular character of Serenity Rose has several of these on the backstory. A partial list:
She freezes a few square miles of lake Michigan when her Mother dies.
She takes a bus with a dozen or so people in it on a joyride 300feet in the are ending in a swamp when her father dies and she's rejected by the girl she had a crush on after failing to protect her from bullies.
Hope from Alone in a Crowd has one of these when she realises her parents have abandoned her and aren't coming back. Made all the more tear-jerking because she could only actively ignore it until she had to say it out loud.
Nelson in Full Frontal Nerdity somehow managed to respond even worse to the Red Wedding in Game of Thrones than his co-gamers, spending an entire strip silent apart from mumbling a little and bearing a traumatised expression.