The hero of the piece: red-haired, extroverted, enthusiastic, and loyal (though not the sharpest crayon in the box). He is also an Occult Detective, which in his case means a lot of running around, meeting supernatural beings and occasionally using his magic hammer and magic marker to rectify things.
Big Guy, Little Guy: played with and somewhat averted: Zombie is never portrayed as a 'dumb but loveable' type, and is often more insightful and realistic then Hanna. That said, the contrast between them is pretty noticeable.
The Pollyanna: Hanna isn't an overwhelming example, but he's hinted to have a pretty harsh past and is still easily the most optimistic and extroverted of the main cast.
{...}/Dotdotdot/Zombie/Gallahad/Imhotep/etc is Hanna's colleague and best friend. He is green, undead and vaguely Asianish. He also (at first glance) appears to have only one expression (of mild misery), but in fact exhibits a wide range of emotions - in a non-showy way.
Oh, and he's the comic's narrator.
Anime Hair: He appears to have wings on his head, but it's really just white tufts of hair.
Dark Is Not Evil: People generally have a negative impression of The Undead, but he's actually a pretty nice guy.
First-Person Smartass: {...}'s narration is deadpan and wry, contrasting the high-energy feel of the comic and pointing out the ridiculous things that happen in it.
Ghost Amnesia: Zombie doesn't even remember what his name was.
Good Scars, Evil Scars: Averted; he's covered in scars (including, although it's yet to be shown, an autopsy incision) that aren't raised but are closed with ugly black thread.
Laser-Guided Amnesia / Identity Amnesia: Dying and being buried for over ten years can do that to you. Subverted in that Zombie's old identity no longer matters to him.
Our Zombies Are Different: He has no interest in mauling people or eating brains, and is a fairly normal guy aside from being dead. Also, he clearly has sapience, though no memory of his past.
The Stoic: Zombie is capable of a range of emotions—and is actually shown to be rather caring and empathetic—but it doesn't register very often on his face, leading people to believe he is one of these.
Hanna lampshades this by keeping tabs of every time Zombie smiles.
Team Mom: Zombie's a bit of an unconventional example, but he is something of an Only Sane Man who tries to keep the others from hurting themselves. Always rushing to protect his allies; Zombie even goes as far as to put himself between friends and their attacker. He even cooks for Hanna!
Rounding up the Power Trio (see above for the other two) is Conrad - a wussy, neurotic, but very, VERY angry designer. He comes to Hanna in the first chapter with an appeal for help and ends up being turned into a vampire. Which sucks because, as a vampire, Conrad is not particularly competent (i.e. the thought of biting some random stranger's filthy neck doesn't fill him with joy and anticipation). Still, he scrapes by the best he can.
Butt Monkey: One of Tessa's favourite things to do seems to be scaring, hurting or otherwise torturing Conrad. And it can only get worse from here on out.
Chew Toy: The poor guy hires a paranormal investigator to get rid of a vampire and ends up becoming one.
A highly shady, sleazy, crabby and unpleasant individual who is Hanna's go-to for all medical purposes. His unique specialization (dealing with non-humans) is probably the only thing that keeps his business going, since he's not even a proper doctor but rather a med-school dropout. His main hobbies seem to be smoking, looking suspicious, fighting with his best friend/partner in crime Lamont and insulting Conrad who he is allegedly "keen on".
Last Name Basis: Referred to as either "Doc" or "Worth". His first name is Luce.
Morality Pet: Hanna kind of seems to be this, a little. Doc has forbidden Hanna in past from dealing with ghosts, apparently because they always hurt him. He knows Hanna will disregard what he forbids him to do, so he urges {...} to look after him.
Satisfied Street Rat: is very content and happy, despite living in filth, being unqualified for his job, having troubles with finances and dealing with the supernatural on a regular basis.
The Smart Guy: Well, he certainly has more sense than Hanna and he DID get into med school...
No, she's not in a band. (It's theater). No, she won't tell you where she buys those clothes. (They are cool though, aren't they?). No, she's not a weird human. (She's a werewolf). And YES, she WILL go berserk on you if you threaten one of her friends.
Action Girl: So far she appears to be one of the most competent protagonists at fighting.
Older than They Look: According to a character Q&A, she became a werewolf in the 80s. Assuming the comic's set in or near the present, she's probably a couple decades or so older than she looks.
Or she was born that way in the 80s. Hanna is 24 and he says Toni is around his age.
Big-eyed, sharp-toothed and ready to say something inappropriate at any given moment, Veser is a 19-year-old college student who happens to harbor several secrets: for one thing, he has Abusive Parents, and for another, one of his parents is not quite human.
We don't know much about his mom, but their relationship probably isn't great either: he once commented that he's lucky she didn't drown him as a baby out of spite.
Half-Human Hybrid: He's is the child of a human and a selkie, although he doesn't really have much to show for it but a wonderfully dysfunctional family.
Handsome Lech: Those shark teeth don't stop the ladies, apparently. He's almost to the point of Anything That Moves, if the artist's doodles are anything to judge from.
Accountant by day, clockwork aficionado by night. Sports the look of a Victorian gentleman and looks good in britches. Also, technically, he has only just appeared in the current storyline.
Asexuality: Stone stated in a recent live stream that he's borderline.
Ensemble Darkhorse: He has a massive fanbase despite having only four lines in the comic so far during a flashback sequence. The author confessed that she's afraid Ples won't live up to everyone's expectations when he's formally introduced.
Evil Overlooker: in the poster. Even if he's probably not evil.
Younger than They Look: He is in his mid-thirties like Doc and (probably) Lamont, but looks considerably older than either of them.
Lee Falun
Once a boring human, now a High Octane Nightmare Fuel ghost who's lost most of his personality and seems to have retained only the negative aspects. When alive, was best friends with Veser's dad, which presupposes a spectacular talent at ignoring the unpleasant but obvious.
Those Two Guys.
Two vampires who are powerful (but low-ranking) and "proper" (meaning they actually do suck blood). They complement each other's personalities nicely and travel everywhere together, to the puzzlement of those around them.
Ambiguously Brown: Casimiro's skin is quite dark for a vampire. Word Of God says that, being Italian, Cas was just very tanned when he died.
Big Brother Mentor: One could imagine that Casimiro's brashness gets him into trouble more often than not. Fortunately, he has the older, wiser Finas to tell him when to sit down and shut up.
Vampire lady and Conrad's sire. She is beautiful and treacherous, as Hanna found the hard way after undoing her curse. Casimiro has some beef with her as well.
Action Girl: Since vampires are very strong, her injuring-people-and-zombies skills are particularly impressive.
Hair Color Dissonance: She's been drawn with either purple or dark green hair. It's actually black. Also, if there's such a thing as Eye Color Dissonance then that applies too, since they're often rendered as pink or purple instead of the red that all vampires have.
Killer Rabbit: This is the horrible vampire that maimed Zombie and killed Conrad.
Doc Worth's partner in crime and friend. Looking like a member of The Mafia, he is no less shady than his colleague - but considerably more polite and pleasant. He does business with the non-human populace of the city and is thus very knowledgeable about the suspicious characters who prowl the night.
Hollywood Pudgy: outside of the comic he'd look 100% average. In-comic, compared to the rest of the characters, all of them rail-thin, he's definitely on the stocky side.
Vampire hunter who has very recently made an appearance in the comic. He is mysophobic (that's "fear of germs" for ya) to the point of wearing a mask and gloves at all times. However, he seems to think his pet ferret Paradox (or Para-Para) is completely clean, and carrying the animal around and kissing him is apparently A-OK.
(That kissing thing was not zoophilia, promise).
Badass Normal: One of the few truly human characters in the cast, and also one of the most Badass.
Malevolent Masked Man: He wears a surgical mask, accompanied by goggles. This means that his only visible facial feature in the vampire-hunting getup is his eyebrows.