These are what we call the 'YMMV items.' Things that some people find in this work. We call them 'your mileage might vary' because not everyone sees these things in the same way. This starts discussions in the trope lists, a thing we don't want. Please use the discussion page if you'd like to discuss any of these items.
Ensemble Darkhorse: Ples has a massive fanbase despite having considerably few lines in the comic. Tessa confessed that she's afraid Ples won't live up to everyone's expectations when he's formally introduced.
People have already started shipping Conrad with vampire hunter Abner VanSlyk... who hasn't even appeared in the comic yet. In this case it's because Conrad is pretty much the whipping bitch of the series. He will get beaten up by, and paired with whatever the fandom thinks is funnier/hotter/more embarrassing for him at the time.
Not only that, but all of said characters tend to form dynamic/entertaining/intriguing relationships with one another as soon as they meet, if they haven't already gotten some connection between them. Zombie quickly becomes protective of Hanna after seeing what kind of trouble the guy gets himself into constantly, Conrad and Worth are guys that yell at each other every time they meet (not to mention the bit about the blood), Worth and Lamont (and Hanna) already know each other, the former two seemingly in a vitriolic relationship, as far as we know Finas and Casimiro are attached to the hip, and Hanna seems to worry over and care about nearly everybody (though Zombie does a bit of this as well), and basically ties the whole cast together.
Hype Aversion: Some fans tend to be somewhat...fanatical. It doesn't help that even long before the hiatus, the update schedule was infamously erratic and completely bonkers, plus Tessa tended to leak future characters before they canonically appear.
Very meta example (spoilered for others' sake): Tessa is seems to be dropping the comic to move onto another project, though she has made no formal announcements about it or the fate of the HiNaBN thus far. After fans spent a year holding online vigils for her because they thought she might be dead or dying, since she seemed to suddenly drop off the face of the internet without a word.
The first look we get of pre-death Zombie is at the bottom of this page. The picture is described as "And somewhere, someone has this in their wallet to remember someone really important to them". Now keep in mind that Zombie can't remember any of his life. (For some added Fridge Horror/ Tear Jerker, consider that the outfit Zombie is wearing in that picture is identical to the one he wore when he was killed. So unless Zombie had a Limited Wardrobe, there's the good chance he died not long after that picture was taken.)