The Simpsons is stuffed to bursting with awesome music, starting with Danny Elfman's main theme (with movie remix by Hans Zimmer!), and continuingonfromthere.
Not to mention the two epicBond theme parodies: Scorpio" (He loves German BEEEEEEEEEEEEEEEEERRRR!), and McBain'stheme, "Blessed be the Guy That Bonds".
"Duff beer for me, Duff beer for you. I'll have a Duff, you have one too."
Games
In their earliest games, the music was rather annoying: typically a looping, low-quality hissing of the theme. However, in more recent games, they've actually used, for example, orchestrated scores. Example: The Orgasmically Awesome soundtrack to The Simpsons Game.
I don't know about you, but Bart Simpson (and others) from The Simpsons Hit & Run (which is actually a very underrated game) has some pretty rockin'themesaswell.