Doctor Zaius, Doctor Zaius... (from the season seven episode, "A Fish Called Selma"note the Day in the Limelight episode for both Troy McClure and Selma, as Selma continues searching for a man so she can have a family before she dies, and Troy McClure tries to resurrect his dead career after years of starring in bad movies and a rumor that he does sexual things to fish)
"Duff beer for me, Duff beer for you. I'll have a Duff, you have one too."
The score for "Apocalypse Cow", especially the part with Lou's training. Bart's combining, too.
People may hate "That 90's Show" as an episode, but no denying that Sadgasm's Margerine is amazing.
In their earliest games, the music was rather annoying: typically a looping, low-quality hissing of the theme. However, in more recent games, they've actually used, for example, orchestrated scores. Example: The Orgasmically Awesome soundtrack to The Simpsons Game.
Bart Simpson (and others) from The Simpsons Hit & Run (which is a very underrated game) has some pretty rockin'themesaswell.