Actor Allusion: When Bernie catches his cousin, Lou, smoking a joint on the patio next to his bedroom, he is understandably annoyed. When he's forced to get somewhat rough with his relative, Lou says "You wanna take a swing, Mr. 3000?!" This is a reference to the film Mr. 3000, where Bernie Mac plays a retired baseball player.
Dueling Shows: This show and My Wife and Kids had the dilemma of sharing the same audience with the same time slot on two opposite networks (Fox and ABC). As the main description states, this became detrimental for The Bernie Mac Show as its ratings weren't up to par with its time slot rival, leading to the abundance of Executive Meddling that crippled the show (keep in mind that Fox's head at the time has screwed over Firefly).
Creator Breakdown: Bernie Mac's now publicly-known pneumonia hampered production during Season 4.
Life Imitates Art: Or rather the opposite. The real Bernie Mac only had only one daughter, versus the three nieces and nephews on the show. Similarly, in one episode, Bernie recalled his earliest years as a broke stand-up comedian, which mirrored his real life journey to stardom.