- Actor Allusion: On episode 97's new year celebration, the imitation request list are filled with some famous characters Mayumi Tanaka voiced.
- Backed By NASA/Backed By JAXA: Both NASA and JAXA advise the manga and anime. In fact, any appearance of space technology had to be approved by both organizations before airing. NASA also allowed part of the movie to be filmed at the Kennedy Space Center.
- Genius Bonus: Look at the hallway at JSC/KSC and JAXA. There are posters of current (during the show's airtime) NASA and JAXA science probes.
- The end credit for ED 3 are ex-Japanese probes.
- I Want My Jet Pack: Sadly, Project Constellation was cancelled in 2010. Humankind will not see Ares and Altair outside of mock ups and this show, though Orion was inherited by its replacement, the Space Launch System.
- Life Imitates Art: A new video released by NASA which details their plan to set up the moon as a launching off point for Mars by 2024 . Their name for the new capsule is Orion.
- Relationship Voice Actor:
- The Straw Hat Pirates, Hiroaki Hirata (Sanji), Mayumi Tanaka (Luffy) and Cho (Brook) as part of the Nanba family. Much certain antics of comedy between the Nanba parents...
- Yuko Sanpei & Miyuki Sawashiro have been friends in other series such as Kimi ni Todoke.
- JoJo's Bizarre Adventure related: Kazuyuki Okitsu and Kenjiro Tsuda were opponents in the 2012-2013 anime series as Jonathan and Bruford. Akio Ohtsuka and Kenji Nomura besides astronauts, they ended up as part of the Pillar Men, Wamuu and Santana. Miyuki Sawashiro is another Joestar descendant in the All-Star Battle videogame, Jolyne, while Hiroaki Hirata is Polnareff and Yuko Sanpei is Narancia.
- Though not directly talked to each other, Ryo Naitou and Kenjiro Tsuda are tennis players, Koharu Konjiki and Sadaharu Inui, both known as data players of their respective schools in The Prince of Tennis. Also, Ryuji Otoji and Seto Kaiba in Yu-Gi-Oh!.
- Miyuki Sawashiro and Ryo Naitou both participated quite for a time in the Di Gi Charat franchise, even Miyuki's first role ever was Puchiko!
Trivia / Space Brothers