- The Other Darrin
- Paul Mercier (who voiced Leon in Resident Evil 4, The Darkside Chronicles, and Degeneration) was replaced with Matthew Mercer (who also voices Leon in Resident Evil 6).
- Sally Cahill (who voiced Ada in Resident Evil 2, Resident Evil 4 and The Darkside Chronicles) was replaced by Courtenay Taylor (who also voiced Ada in Resident Evil 6).
- Playing Against Type: Wendee Lee, a villain, no way!
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