- When Leon shoots JD, he was trying to disable him in the same way he does to Sasha in the ending, as otherwise he would have went straight for JD's head. This is because JD hasn't bled from his eyes yet indicating that the Plaga hasn't taken complete hold and there might still be a chance to save him. JD would not bleed from the eyes until after he was shot, but it seems that it was too late already.
- When the Super Tyrants are taken down by fighters. It has been noted during numerous Resi media that Tyrants, while massively powerful against ground forces, they will almost always lose against vehicles, this movie proves once and for all that the "ultimate lifeform" would actually be pretty useless in a real battlefield.
Fridge / Resident Evil: Damnation