- Listening to Tannis' ECHO logs. She starts of as a sane woman, yet you could already hear tinges of sadness and resignation, which is to be expected since her first set of tapes details being the only survivor in the death world that is Pandora. You explore how the combination of isolation and ubiquitous danger has permanently damaged her brain, to the point where she tried making friends with the bandits. Whenever you set off for your next mission after speaking with her, she softly says "Oh, you're leaving?" You're the first person, perhaps friend, that she's made and she doesn't want you to go just yet,
- The story and eventual fate of Hank Reiss in the Zombie Island DLC. His ECHO logs detail his love for his wife and children, one of whom made a macaroni hat for him that he wears every day. He ends up transforming into a were-skag and killed in self-defence.
- TK Baha's death.
- Thankfully, the Zombie Island DLC brings him back. As a zombie. But at least he is funny and allied, and naturally, incredibly cheerful.
- Every time you defeat a Rakk Hive. Shortly after collapsing, their innards appear to, quite literally, explode from the inside, exposing their ribcage and pulsating organs for all to see.. and the poor creatures are visibly still breathing.
- Anytime you come across a damaged Claptrap unit. The poor thing will be writhing and crying in pain on the ground, presumably after being tortured by bandits. Thankfully you can help repair the poor guys and gain some nice rewards in the process.
Tear Jerker / Borderlands