There was a 1960s singing group called Spanky and Our Gang, which derived its name from lead singer Elaine "Spanky" McFarlane's facial resemblance to George "Spanky" McFarland (including their similar surnames).
In "Marge vs. the Monorail", Mayor Quimby asks Leonard Nimoy whether he was one of the Little Rascals.
In "Homer the Smithers", Marge is surprised at Homer getting up at 4:30 and reminds him that The Little Rascals isn't on until 6:00.
In "Radioactive Man", Moe reveals that he used to be one of the Little Rascals, named "Stinky", until he killed the original Alfalfa.
In "Wild Barts Can't Be Broken", the familiar theme music plays when Bart and his friends walk through a fence. In addition, Milhouse is dressed as Alfalfa, and a dog resembling Pete the Pup follows them.
In "The Musk Who Fell to Earth", Kent Brockman reports that the last of the Little Rascals has died.