"Litter Kills.... Literally" is widely considered the only sincerely dramatic episode of the entire show, despite being a Take That! against the Tonight, Someone Dies trope. This is because, it focuses more on the characters grieving rather than Paunce himself, and watching someone you know and care about (assuming you care about the main characters) deal with the loss of someone close to them is a lot more relatable than being expected to mourn the loss of someone you never knew.
The series in general: the way all the characters are either flanderized or direct opposites of their original genetic copies could be interpreted as just because they're based on someone great, doesn't mean that they have the ability to measure up to them. They're the ones in control of their destinies, they shape who they are. That's why Gandhi acts the way he does, he doesn't feel he can live up to his legacy.
Research has shown that the real Cleopatra was anywhere between simply above average to ugly in appearance but most likely not incredibly beautiful, but since Cleo is rich she may have got plastic surgery.
Why would the secret board of shadowy directors clone Hitler?
Hey, the guy was an extremely charismatic leader, which seems to be something the board would want to harness...
With how the other clones turned out, he was likely a tireless worker for world peace and equality.
Indeed, the clone of Hitler has an arm band with a peace sign on it.
Why not? They cloned Genghis Khan, who was a brutal warlord, as well. Whatever DNA they can find.
They're a shadowy and malevolent conspiracy wanting to use the clones as soldiers. If they're already cloning so many famous people, why wouldn't they clone Hitler?
"Sleep of Faith": Sleep deprivation is played for laughs as an absurd G-Rated Drug, but it becomes this when you realize that it can actually be a very serious problem.
The series ends with every single character sans Scudworth and Mr. Buttlertron frozen. While this allows the two of them to get away scot free, they now have to live with the fact that they've left dozens of people trapped in suspended animation, and most likely keep up a very elaborate lie to ensure that they never get found out.
"Escape to Beer Mountain: A Rope of Sand": When Gandhi points finger guns at JFK, JFK recoils at the gesture out of fright, referencing how the real JFK died.
To make a clone of someone, you need their DNA. There's a clone of Jesus. Where did they find Jesus's DNA?
Fridge Brilliance: They didn't have Jesus' DNA. Note that whatever your beliefs on Jesus' racial background, it's highly unlikely that He was of Latino American descent as depicted in Clone High. Venturing into Wild Mass Guessing territory, the likeliest explanation is that he was cloned from the suspect DNA of the Shroud of Turin.
The likeliest explanation is that they probably just cloned some Latino guy named Jesús.
Another plausible theory is that he's actually Ambiguously Brown, with his accent simply deriving from having a Latin foster family.
Maybe they found a genuine nail, thorny crown, or bit of cross?
Shroud of Turin.
In the third episode, A.D.D.: The Last 'D' is for Disorder, it's revealed Joan of Arc wears a retainer. Wouldn't that mean the original Joan of Arc had a deformed upper jaw? What makes it worse is that she says 'If this causes an overbite, [Gandhi], you're so dead.'
Not to mention the real JFK suffered from various health problems, most notably chronic back pain.