These are what we call the 'YMMV items.' Things that some people find in this work. We call them 'your mileage might vary' because not everyone sees these things in the same way. This starts discussions in the trope lists, a thing we don't want. Please use the discussion page if you'd like to discuss any of these items.
Angst? What Angst?: By any metric, Megamind had a spectacularly crappy life and upbringing- home planet destroyed, raised in jail, bullied at school, no friends except for Minion- but doesn't seem particularly bothered by most of it.
Broken Base: While Megamind is generally well recieved, it differs between those who find it to be a hilarious masterpiece while others thinks that, while it is good, it could have been alot funnier and didn't quite reach its potential.
Draco in Leather Pants: There are a handful of people who romanticize Hal as a loveable loser who just needed a shot at love. They fail to realise that Hal is a deconstruction of that character type and in truth is an entitled man-child who ended up threatening the entire city, simply because he got friend-zoned.
Ear Worm: ♪ I have eyes. That can see. Right through leeeeeeead. ♪
Foe Yay: Like woah between Megamind and Metro Man: Megamind goes into mourning over Metro Man, bringing flowers to his statue and lamenting about all the battles they'll now never have and how it's "not the same" without him.
Megamind is visibly relieved Metro Man isn't dead when he sees his cape flying from the explosion, a long moment before his "Oh Crap, he's alive and coming towards me."
Megamind and Roxanne have a little bit of this going on among them, right before Roxanne hugs Megamind.
There's also the scene where Roxanne takes Megamind to Metro Man's hideout. He's practically squeeing at all of the stuff and even puts on Metro Man's cape. Roxanne seems uncertain how to take his reaction.
Freud Was Right: When he arrived on Earth, Megamind was set to land in a beautiful mansion with a rich father and loving mother.... only to be shunted out of the way by the arrival of Metro Man. They then grow up to be rivals, with Megamind forever trying to 'take' something from Metro Man in return. If you chose to take it all very seriously, one might see shades of an Oedipus complex.
Genius Bonus: If you look carefully during the scene where the death ray is firing at Metro Man, you can tell that Metro City is in Michigan. Before automobiles moved in, copper mining was Michigan's biggest industry. Metro Man's weakness is copper. Weaksauce Weakness indeed (if he hadn't been making that up). Probably just a neat little coincidence, but cool if it was intentional.
Jerkass Woobie: Megamind himself before his Heel-Face Turn. His villainy is closer to the Poke the Poodle variety, but he still regularly kidnaps someone, threatens them with bodily harm, and (unsuccessfully) tries to kill his nemesis. On the other hand, his planet was destroyed, had a potential family stolen from him by a coincidence, grew up in a prison and was ostracised as a child for (arguably) doing the exact same things Metroman did.
Bernard. How would you feel if you woke up in a washing machine after God knows how long, only to get immediately knocked out again by a mechanical fish-ape? Poor guy.
Moral Event Horizon: Titan going on an rampage over Roxanne rejecting him is bad enough but willing to kill Megamind crossed this.
Most Wonderful Sound: The opening notes of "Welcome to the Jungle." In-story too: just look at the expression on Roxanne's face.
One-Scene Wonder: The real Bernard appears in two scenes. One has him acting cold towards Roxanne and mocking Megamind's "costume" before being dehydrated, and the other has him rehydrated by Minion and getting whacked by his stick.
Squick: "Come out you little freak! I wanna see what that BIG BRAIN LOOKS LIKE ON THE PAVEMENT!"
They Wasted a Perfectly Good Plot/They Plotted a Perfectly Good Waste: As Megamind talks to Minion about who they should make into a hero, and how this hero should be "someone of noble heart and mind, who puts the wellfare of others above their own", he is interrupted by his mobile ringing. It's Roxanne. She is right outside. Because she tracked him down to stop him.
You have to admit, Metro Man briefly coming back to team up with Megamind would have made a pretty cool finale.