Adaptation First: The NES version was the first version released in North America, as the MSX2 standard was never available in America. Although technically a port, it has enough differences to be considered a separate game.
Averted with Snake's Revenge, which he actually considers to be a good game.
Hey, It's That Guy!: David Hayter, the voice of Solid and Naked Snake, wrote (among other things) the scripts for the first two X-Men movies and the Watchmen movie.
Hey Its That Guyver. Hayter is credited as Sean Barker (his character in Guyver) in the early trial versions of the first Metal Gear Solid.
The Fear's voice wasn't the first time his voice actor (Michael Bell) voiced someone from a military unit called Cobra. Neither were Volgin or The Pain.
In the original, The DARPA Chief was Gray Fox (and Stillman), and both were also the Grim Reaper, Luke Cage and Aku Aku. In The Twin Snakes, the Chief retained his voice actor, but Gray Fox was recast. He was then voiced by the same guy who did Bubsy The Bobcat and Pinky.
Rob Paulsen also voiced Raphael, and Gray Fox is killed by Leonardo. Eerie coincidence!
The Peace Walker has Bubbles voicing Paz. And when turned on Japanese voice, she's Fate Testarossa. Which makes it more surprising when you realize that she's the Big Bad.