Mecha-Cthulhu may be out there, and he may want to eat your face, but if you have a big enough gun, you can kick his eldritch, multidimensional ass.
I'm proud that I wrote a comic where a Lovecraftian horror is stopped in its tendrilly tracks by a stuffed animal.
Oderus: The root of all evil and hatred and shame.../ So many victims, so many names / But... they are all the same / Ereshkigal? Charun? Helel ben Shara? Lucifer? Satan? We would know who you are!
The Devil: Welcome GWAR to my domain / It's nice to be called on by so many names / Now what's this I hear about you kicking my ass?
— GWAR, The One Who Will Not Be Named
Q: You hit me! Picard never hit me!
Sisko: I'm not Picard.
Wonder Woman: There has to be another way...
Hawkgirl: There is. We go to Icthulthu's world and kick his slimy a-
Grundy: Birdnose is right!
— Justice League, "The Terror Beyond"
No matter how subtle the Jenoine, a knife between the shoulder blades will seriously cramp its style.
— Vladimir Taltos, Issola
I have already killed one god today. If I had known today was a day for killing gods, I would have paced myself.
So I brought in Death, and Death went around killing things, and then I brought in God, and Death killed God, and then I had to kill him...
Ivo Shandor: I am a god!
Egon Spengler: We eat gods for breakfast.
You're not even really alive. You're just a machine... and machines can be broken!
— Commander Shepard, Mass Effect 1
Sovereign - "the vanguard of our destruction". How's that working out for ya, big guy?
— Shepard to a piece of Reaper debris, Mass Effect 3 Leviathan
Personally, I've always liked tackling legends. It's so much fun to let the air out of them.
Don't worry about the eldritch horror, we've got a plan for this contingency — as soon as we've evac'd we'll just pop a brace of Storm Shadows on his ass and send him right back down where he came from.
— Captain Alan Barnes, The Jennifer Morgue
It's a funny thing about the old gods. You think that just because they're old, they must be difficult to kill. But when the fighting starts, they go down just like anybody else. They're not stronger, they're just older.
— The Beast/ Martin Chatwin, The Magicians.
Oooooh! I just kicked Q in the joy department! That can't be smart!... Let's do it again!
Zeus: The Sisters [of Fate] have aided you?!
Kratos: The Sisters are dead.
— God of War II
Steve: Ph-nglui mglw'nafh Cthulhu R'lyeh wgah'nagl fhtagn!
Terry: Steve! No!
Cthulhu: Who dares summon mighty Cthulhu?
Steve: G'day Cthulhu. Up for a wrestle?
Spiritia: Iris, you're wrong. I won because everyone was cheering me on. No one is ever truly alone. It's because you couldn't believe in others... because you couldn't love your fellow man... That's why you lost.
...Is that all? My blade is telling me to spill your blood, and I am inclined to obey. I don't care if you're a God, a human, or even an insect; I will rip you apart just the same.
— Grolla, RosenkreuzStilette
Call me... the Guarding Dark. Imagine how powerful I must be. And now, get out of town.
The Profound Darkness: Hello, my name is the Profound Darkness, and I got beaten to death by a teenage kid and his motley crew of heroes and misfits.
Darksol, Iom, Ganondorf, Lavos and Valmar: Hello, Profound Darkness...
Tycho: Let me put it this way: how would you like to punch a God?
Tycho: Good man.
How can this be? After I've absorbed God? How can this mere human, this alchemist, manage to... (Gets punched out by Ed)
— Father, Fullmetal Alchemist
See, cuz right now this is the part in any RPG ever where you have to kill God. It's pretty rad. I love killing God, I do it every day. You know, some people have breakfast, I kill God, with my super-giant house-sized sword, you know, it has 3 mortages in it, 2 families can live in it, but instead I use it as a weapon; it's pretty rad.
Loki: ENOUGH! You are, all of you, beneath me! I am a GOD, you dull creature! And I will NOT be bullied by-
Chakravartin: You have exceeded my expectations. I praise you. You are indeed the one to inherit this world. Gaea must be led by one of its own. Now that you have become a perfect being, I may now leave this world, and save other worlds in need of my guidance. Come, and join your daughter (...) (extends hand) I am counting on you.
Asura: (extends arm) I refuse.
To a Many-Angled One, we impoverished entities who are stranded in three-plus-one dimensions are fairly harmless; nevertheless, even the inhabitants of flatland can inflict a nasty paper cut upon the unwary on occasion.