In the "Dark Dungeons: The Movie!", Debbie ends up summoning Cthulhu by playing too much D&D and in the end she defeats him through the power of prayer.
In The Gamers Alliance, the heroes of the Grand Alliance work together and defeat Nergal, the God of War, in
combat.
In the Crinoverse, this happens a lot. The final Chicago Avengers adventure had the heroes facing off with Omega, a being who destroys entire universes. First his armor is blown off, and then he's punched so hard he explodes.
In the Whateley Universe, Sara Waite fights The Kellith in dreamspace with a knife. And wins. Even if Sara Waite is The Kellith, or one is part of the other, or they're a duality, or something.
It actually makes sense in context: the 'Kellith' in the dream represents the magical brainwashing her supposed high priest was trying to inflict on her. Of course, that technically makes it not quite an example of this trope — but then the Whateleyverse also has Tennyo, who apparently eatsEldritch Abominations, demons, and the like. (The jury's still out on whether she counts as one herself.)
In The Salvation War, this trope is definitely in play. In Armageddon?, the human race kills off Satan and in PantheocideYahweh, the entity behind the Abrahamic deity is next on their list. Powerful as heck and incredibly long-lived (functionally immortal against old age? Maybe), but not invulnerable...
As it happens, Yahweh was punched out by the Archangel Michael, but the human race did manage to punch out Uriel, the Angel of Death though.
Various episodes of ONA Haiyore! Nyarko-san have Mahiro Yasaka stab Nyarko's hand with an elder sign (read "mundane fork"). Of cause it's parody, but consider that she's Nyarlathotep...
"But this was the House of Red Fireflies, the greatest whorehouse in the world, and the mistress was a plump, matronly woman who had once killed a god with a broken beer bottle, and she looked at the fish, and she nodded."
In Marvels RPG, the Earth's heroes defeated theGalactusSwarm, being the first species in the universe to complete this task. Generation X defeating Nyx had the same effect.
In the second season finale of Marble Hornets, Jay is sleeping inn his hotel room when he hears Jessica scream from the adjoining room. He jumps up to help her, but then stops and turns around. The Operator has materialized into his room behind him. Jay pauses for a minute, as if considering whether to run away or not, but then just takes thepath of greatest awesomeness and tackles the Operator out a window.
In the famed creepypastaRussian Sleep Experiment, the best defense against the physical embodiment of mankind's daytime fears is found to be a TT-33 pistol.
Jappleack's plan to defeat the Titan of Honesty, an Evil God who can travel through multiple planes of existence and devoured the other five Titans? Eat him. She succeeds.
Twilight: You're talking about a centuries-old inter-dimensional leviathan the size of a planet who devours entire planes of existence. Jappleack, what are you thinking? You can't eat Appelox!
In the Grand Finale, Rainbow Dash, after coming Back from the Dead and causing reality to reset with a Sonic Rainboom, ends up defeating Discord. Possibly justified since she used the Sword of the Holy Titans summoned by Twilight, which Twilight Prime considered about the only spell that may have been effective against Discord's father Appelox if they could've found someone to wield it.
The SCP Foundation is devoted to containing and studying Cthulhu-grade anomalies that threaten or endanger human sanity, existence, and reality as we know it merely by existing.
Each of the creatures is given a nickname. SCP-343, one of the entities contained, is so powerful it's nickname is simply "God".
In 'The Camping Webisode' of DSBT Insani T, Alex makes a mention to Killer Monster of all the powerful beings he and the others defeated in the past, not fazed by Killer Monster's threat.
Alex: We have taken out mismatched freaks of nature created by ancient serpents, mad scientists with powerfull monsters under their command, and demons who can take over the planet! You don't think we can kill some fire-breathing beast?!
