In The Gamers Alliance, the heroes of the Grand Alliance work together and defeat Nergal, the God of War, in combat.
In the Whateley Universe, Sara Waite fights The Kellith in dreamspace with a knife. And wins. Even if Sara Waite is The Kellith, or one is part of the other, or they're a duality, or something.
It actually makes sense in context: the 'Kellith' in the dream represents the magical brainwashing her supposed high priest was trying to inflict on her. Of course, that technically makes it not quite an example of this trope — but then the Whateleyverse also has Tennyo, who apparently eatsEldritch Abominations, demons, and the like. (The jury's still out on whether she counts as one herself.)
In The Salvation War, this trope is definitely in play. In Armageddon?, the human race kills off Satan and in PantheocideYahweh, the entity behind the Abrahamic deity is next on their list. Powerful as heck and incredibly long-lived (functionally immortal against old age? Maybe), but not invulnerable...
As it happens, Yahweh was punched out by the Archangel Michael, but the human race did manage to punch out Uriel, the Angel of Death though.
Various episodes of ONA Haiyore! Nyarko-san have Mahiro Yasaka stab Nyarko's hand with an elder sign (read "mundane fork"). Of cause it's parody, but consider that she's Nyarlathotep...
"But this was the House of Red Fireflies, the greatest whorehouse in the world, and the mistress was a plump, matronly woman who had once killed a god with a broken beer bottle, and she looked at the fish, and she nodded."
In Marvels RPG, the Earth's heroes defeated theGalactusSwarm, being the first species in the universe to complete this task. Generation X defeating Nyx had the same effect.
In the second season finale of Marble Hornets, Jay is sleeping inn his hotel room when he hears Jessica scream from the adjoining room. He jumps up to help her, but then stops and turns around. The Operator has materialized into his room behind him. Jay pauses for a minute, as if considering whether to run away or not, but then just takes thepath of greatest awesomeness and tackles the Operator out a window.
In the famed creepypastaRussian Sleep Experiment, the best defense against the physical embodiment of mankind's daytime fears is found to be a TT-33 pistol.
