Hilarious in Hindsight: Thor is turned into a woman through Loki's meddling. Fast forward to 2010, and Loki is turned into a woman through Loki's meddling. Fast forward again to 2014 and a female Thor has been announced in the main contain city.
Moment of Awesome: The main page quote. Black Bolt's swan song. Tony Stark buys the world more time. Reed's bravery and steadfastness. Basically, most of the whole series.
Never Live It Down: Whenever someone mentions the version of Spider-Man from this series, the focus is usually on the fact that he's fat and in a costume that doesn't fit. When featured in artwork for Spider-Verse, Earth-X Peter is seen eating a hamburger. This is despite that he's never shown eating or stuffing his face in the main story, and in the following two series Peter lost a significant amount of weight.
Critical Research Failure: Mephisto's plot to create alternate timelines actually makes sense; but Richmond's attempt to explain it badly garbles concepts of time and dimensionality.
Squick: "With the exception of a few opportunists who anticipated the coming need and secretly bred and sold animal life through the underground, Wakanda was the only known nation where mammal and fowl hasn't been hunted down and consumed. I still feel badly about Howard (the Duck)." The Skull had a roast fowl dinner when he first arrived at New York.
Arc Welding: Sometimes it worked, like making all bestial powers related. And sometimes it didn't, like saying Colossus went back in time & became Mister Sinsiter.
Funny Moments: Peter Parker seeing two versions of his daughter having a Let's You and Him Fight lampshades that they're probably going to make up and he'll end up with both of them living out of his home. He then starts raving about how miserably crazy his life is and what did he do to deserve it, all stopped by Old Man Hyperion very quickly putting his hand over his mouth.
They Wasted a Perfectly Good Plot: Well, more like they just couldn't, what with waning popularity and all. Colossus possessed the knowledge to bring a person back to life using Limbo. When Kurt asks Aaron why he never used it, Aaron answers; "Who says he didn't?"
Also they never explored how Xen was formed. That would have been an interesting story.