Wile E. uses his new chemistry lab to try to catch the Road Runner, from making invisible paint to using a jet-powered spray container, none of which are successful.
Notable for being the last Rudy Larriva short of the series.
- End of an Era: The final short directed by Rudy Larriva.
- Iris Out: A rarity during the era of when the "Abstract WB" logo sequences were in use. The camera zooms into the Coyote's eye with his pupil transforming into the Road Runner, giving off his signature BEEP and zooming away.
- Recycled Script: The train tunnel scene is copied from the same gag in the 1958 Bugs Bunny cartoon Hare-Less Wolf, with Charles M. Wolf/Wile E. Coyote chasing Bugs Bunny/the Road Runner into the tunnel, Bugs Bunny/the Road Runner pretending to be a train and chasing Wolf/Wile E. out of the tunnel, Wolf/Wile E. getting wise and chasing Bugs/the Road Runner back in and does not seem fooled by another approaching headlight, but it turns out to be a real train that hits Wolf/Wile E.
- Took a Level in Jerkass: The Road Runner, of all characters, actually sensing danger and playing some mean tricks on Wile E. Coyote, something he never did in the Chuck Jones shorts.
- Visible Invisibility: When the Coyote uses the invisible paint.