Once the scandals finally exploded and made Twenty-One synonymous with rigging and cheating, it unsurprisingly put host and producer Jack Barry and partner Dan Enright in the Hollywood hall of shame. They were not able to create another show until 1972, when The Joker's Wild premiered.
The rigging itself also became a Creator Killer to champion and NBC anchor Charles Van Doren when he admitted he was part of the rigging, and it took his tenure at Columbia University with it. He moved on to be an editor and writer of several books and encyclopedias.
The scandals also led to TV laws that are still enforced today, which ended the sponsors' ability to control the show after they tried to take the reins for the 50's.
Franchise Killer: After NBC was forced to pull Twenty-One from their schedule when the scandals surfaced, the show wasn't even touched for another 40 years, barring a few attempts to retool it. NBC finally gave the program another shot in 2000 after Who Wants to Be a Millionaire? revived the big-money quiz show genre months prior, and it ran for six months but produced some big, legit wins.
Genre-Killer: The quiz show scandals (which Twenty-One came to symbolize, although as mentioned on the main page it wasn't the one to cause the investigations) discredited quizzes for some time. It wasn't until The '70s that American viewers would trust such shows again on a large-scale basis, and 1999 for big-money quizzes to come back into vogue.
The Hollywood Blacklist: Towards the end of the original version's run, director Charles S. Dubin was fired from both the show and NBC for refusing to testify before Congress over whether or not he had ever been a Communist himself.
Prop Recycling: The giant monitor thing used in the 1982 pilot's bonus round was later recycled by producer Richard Kline for Break the Bank (1985), where it was used as the Number Jumbler display.