- Billing Displacement: Jennifer Jason Leigh receives top billing, but Keir Gilchrist plays the main protagonist, Sam.
- Creator Backlash: After two seasons, Keir Gilchrist decided he felt uncomfortable being a neurotypical man portraying someone with autism and so backed out of the show as a result.
- Dawson Casting: The Gardner kids and their significant others – as of the start of Season 1, actors Keir Gilchrist (a month shy of 25), Jenna Boyd (24), Brigette Lundy-Paine (24), and Graham Rogers (26) play Sam (17), Paige (17), Casey (16), and Evan (18) respectively.
- Fake American: English-Canadian Keir Gilchrist as American Sam Gardner.
- The Other Darrin: In the Latin American Spanish dub, in the second season Adriana Nuñez dubs Elsa, in place of Cony Madera, who dubbed her in the first season.
- Queer Character, Queer Actor: The bisexual Casey Gardner is played by queer and non-binary actor Brigette Lundy Paine.
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