The bad ending easily counts. History Repeats doesn't even begin to cover it. In the same vein, Julius Mode, while an awesome call-back to Dracula's Curse, can just as easily be considered this, since this mode is a hypothetical scenario of what would happen if the aforementioned bad ending was canon instead of the good ending.
If Julius is the one to land the final blow against Dracula!Soma, he apologizes to his former friend for being unable to save him.
Or, if you're feeling particularly cruel, you can make Alucard land the final blow, forcing him to kill his father for the thirdtime.
To twist the knife, listen carefully to Dracula!Soma's roar upon entering his second phase. Very carefully. Sounds like a heavily distorted "Ha...kuba...", doesn't it? He's still grieving for her. And he dies completely unaware of the truth.
Even worse? Consider this ending path when interacting with Yoko during some of the visits to her shop. A first time playthrough would have all her playful teasing and prodding about Soma's feelings for Mina seem innocent enough, but it takes on a far darker tone when it comes to light that in many ways, she's the tipping point for whether Soma will lose himself to the powers within him or not on a repeat playthrough... suddenly a slightly comical scene isn't so funny anymore...