The gang takes the train on the way to a conference. Guest star Summer Glau is a passenger on the train; Raj and Howard try to make conversation with her. Sheldon forgot his flash drive at home and he asks Penny to retrieve it.
- Actor Allusion: Penny briefly talks about getting to play Anne Frank. On 8 Simple Rules, Kaley Cuoco's character Bridget played Anne Frank in a School Play episode.
- Cutting the Knot: As Sheldon gives Penny instructions on how to open the puzzle box hiding the flash drive, she asks if the box has any sentimental value. When he says that it doesn't, she simply smashes it open with her foot.
- Fake High: Raj gets drunk on beer to hit on Summer. The guys discover that he was actually drinking non-alcoholic beer and Raj is only talking to her due to the Placebo Effect. Once Raj is informed of this, he goes quiet and walks away.
- Running Gag: Raj's selective mutism and Sheldon's paranoia about anyone going in his room.