Pick any MacGuffin from any of the main games, and prepare to be horrified at the results. El Dorado? Zombifying anthrax. The Cintamani Stone? A tree full of Psycho Serum. The "djinn" at the heart of Iram of the Pillars? Concentrated Mind Rape. The legendary golden city? Irradiated and deadly. Captain Avery's lost treasure and utopia of Libertalia? Nothing wrong with the treasure, but its sheer size and scope caused everyone who knew about it to slaughter each other out of greed and paranoia. Is it any wonder why all of them were sealed away?