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  • At the end of "Malibu Fire", in keeping with the Running Gag of Mark being mistaken for Peter Graves (and Amanda for Whitney Houston), Jesse is mistaken by that same reporter for Michael J. Fox. Rather than deny it, Jesse instead launches into a hilarious on-the-spot impression.
  • The end of one episode where the killer is a con artist who'd been posing as a doctor. He and his female accomplice are about to escape in a private plane when Mark and the cops bust them. Mark tells the woman she should be thanking him as her partner "is no more a licensed pilot than he is a licensed doctor" and she realizes the guy barely knew how to fly.
  • The entirety of Randy Wolfe's character in "A Mime is a Terrible Thing to Waste." The woman is just this crazy blend of Genki Girl, Granola Girl, and Badass Adorable, as well as being a Jack of All Trades.
  • All of Tim Conrad's inept attempts to kill Harvey Huckaby.
  • In the episode "The Busy Body", while dining out, a female cop approaches Mark telling him he's under arrest, his bafflement turning into mortification as she quickly reveals she is actually a stripper someone hired for him. He is visibly trying to slide under the table while Jack has a laugh at his expense. And to top it all off, she handcuffs him to the table - with actual handcuffs, not trick ones.
  • "Till Death Do Us Part" is an absolute goldmine of comedy, from the over-the-top fantasy of the two murderers perfect crime to having every single step go completely wrong in reality.
  • "A Very Fatal Funeral" centers on the board members of a charity being murdered at the funerals of the last one to be killed. By the time of the last member's funeral, the priest speeds through the last rites and books it the second he's done.
  • In "My Four Husbands", Mark enlists Norman and Delores to investigate a lawyer's office in attempts to clear Pamela Dorn. While in the office, someone starts coming through the door, so they hide under the lawyer's desk. The ones coming through the door turn out to be a security guard and maid, who proceed to have sex on the desk with Norman and Delores trapped underneath. Their faces are a picture.
  • In "Murder Two: Part Two", Matlock shows a witness on the stand a receipt for another character's stay at a motel. One of the charges on the receipt is a pay-per-view of "Barney Meets Godzilla". What on Earth could be happening in that movie?
  • Everything about Dr. Danger in the "Trash TV" two-parter is hilariously inaccurate to Mark Sloan's exploits (to his chagrin), from Mark being reimagined into a dashing young man with the name of Dr. Sloane who sleeps with his female patients, to him casually violating the Hippocratic Oath by shooting villains, to Jesse appearing as an ass-kicking female version. Then, when the lead actor Derek Shaw unexpectedly gets killed, the show's producer decides to take his place as Dr. Sloane (at least until he seemingly shoots one of the extras on-set by mistake).
  • During "Murder at the Telethon" while Mark and the others are trying to save Buddy Blake, Norman is hosting the telethon and trying to spin the tragedy as a demonstration of why the emergency room is so important, noting that if they had been closed Buddy might have died. Immediately he is informed that in fact, they were unable to save Buddy, at which point Norman informs the audience of this, and without a moment's hesitation continues on to say that they will continue the Telethon, because that's what Buddy would have wanted.

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