- Box Office Bomb: The film only grossed $14.6 million on a $15 million budget and was one of the big flops of the 1985 Christmas season (possibly due to the Multiple Endings gimmick). However, it became a Cult Classic on video and cable (where all three endings appeared together).
- Hey, It's That Guy!: Who murdered the lead singer of Fear? Was it Doc Brown? Lily Von Schtupp? Dave St. Hubbins? Leon Calp? Dana Lambert? Captain Doreen Lewis? Or even... Doctor Frank N. Furter??!!
- Throw It In: The famous "I hated her sooooooooooooooooo much... Flames! Flames on the side of my face! Breathing... breathe-... heaving breaths..." scene resulted from Madeleine Kahn taking the original line as written in the script (" Yes. I did it. I killed Yvette. I hated her.") and adding onto it, with the knowledge of director Jonathan Lynn (and no one else). You can see Tim Curry trying not to laugh, while Martin Mull and Christopher Lloyd are looking around wondering who gave her those lines.
- Vindicated by Cable: HBO and broadcasts of this relatively inoffensive movie allowed Clue to stop being an Old Shame for the cast and crew and became a cult hit, even with an Audience Participation midnight show, as detailed in a long article by Buzzfeed.
- What Could Have Been: So many things could have been even greater...
- Carrie Fisher was supposed to play Miss Scarlet, but she had to go to rehab a week before filming began.
- Director Jonathan Lynn was a fan of Rowan Atkinson and wanted him to play Wadsworth, but the producers said that Atkinson wasn't a big enough name for American audiences. So instead he cast lifelong friend Tim Curry.
- A fourth ending was filmed, but left out because it is less humorous than the others. In this one, Wadsworth killed all the victims due to his disgust at their behavior and a sick need for perfection, and reveals that he has poisoned the other characters as well. The FBI shows up, and Wadsworth confesses by beginning to reenact the plot again. When he gets to the part where he answers the door for Colonel Mustard, he flees. Wadsworth attempts to get away in a police vehicle, but hears a doberman growling from the backseat, and is attacked.