In episode 15 of the Ask That Guy with the Glasses... well, something like this happens. (For bonus points, this comes in the wake of a particularly lengthy and disturbing rant about starving a Furby to death.) That Guy responds to a question down the vein of "how do I know I'm real, and not a product of my own imagination?" with unusual vitriol, until it descends into a self-serving rant about himself and his own twisted villainy.
That Guy: ...I don't say this often, but you are wrong, and I am right. I mean, suppose I was the figment of someone else's dream and that the dreamer out there was actually a good, rational person with — eugh! — a conscience. I mean, wouldn't he have gotten rid of me a long time ago? I mean, wouldn't he have the decency to get rid of such concentrated evil like me? No! No! There is no dreamer, and evil. Always. Wins. Thus showing that there is no good in the world, and evil is always rewarded. That's the way it is, and that's the way I always (poof)
On the final episode of Robo Girl the villain is explaining the mind-screwing origin of The Host to the protagonist when she grabs her throat, saying, "You talk too much!"
Lex Luthor: Say goodbye to the world you know! From this moment on, you are all at the mercy of Lex Luthor, the greatest criminal mind of our—
Green Goblin: AHHHH, SHUT UP! (knocks him down with a pumpkin bomb)
At the end of Spoony's review of Ultima IX, the Guardian offers Spoony three choices: destroy the Black Gate, eventually driving away his friends and fans; embrace madness and end humanity's suffering through death; or go through the Black Gate and become one with the Guardian, their combined power making any world theirs for the taking. Spoony responds with a seeming non-sequitir:
Guardian: I guess we all know how this ends, don't we Avatar?
Laura: No, I'm not just gonna give up. Maybe you're right, maybe I am a child: a 19-year-old who never left her city limits before she got here. Who thought that university was gonna be some big adventure full of books to read and parties to dance at. Who never thought anything bad could actually happen. Well...turns out the world doesn't work exactly how I thought it would. My university is creepy, and parties are full of numbskulls getting hammered, and girls go missing and nobody seems to care, and maybe that's just the way it is, but that does not mean that I have to accept it. I deserve better. Betty deserves better. Hell...even you deserve better.
Rip Van Winkle of Hellsing Ultimate Abridged gets a spectacular one from Alucard when she calls him a "racist, cis-gendered, patriarch-propagating, misogynistic pig".
Alucard:[catches one of Rip's bullets with his teeth] The funny thing is... [crushes the bullet] in any other circumstance, you might have had a point there. Except my boss is a woman, I was a chick in the 40s, I hate everyone equally, and there's no one alive who can comprehend my sexual preference. So in other words, Ms. Van Winkle, CH-CH-CH-CHECK YOUR PRIVILEGE![socks Rip across the jaw]
Magnus delivers one of these to the Animus Bell, a Grand Relic that tries to enthrall people into using it.
Animus Bell: How would you like to live forever?
Magnus: I'd hate it. Shut the fuck up.
In "Dust," the murderer tries to convince the party that Jeremiah's death was a small price to pay in exchange for saving Dry River from the specter of government corruption. After a short back-and-forth of arguing about it, Errol ends it by saying "Why are we having this fucking conversation? You killed a boy in the street."