In episode 15 of the Ask That Guy with the Glasses... well, something like this happens. (For bonus points, this comes in the wake of a particularly lengthy and disturbing rant about starving a Furby to death.) That Guy responds to a question down the vein of "how do I know I'm real, and not a product of my own imagination?" with unusual vitriol, until it descends into a self-serving rant about himself and his own twisted villainy.
That Guy: ...I don't say this often, but you are wrong, and I am right. I mean, suppose I was the figment of someone else's dream and that the dreamer out there was actually a good, rational person with — eugh! — a conscience. I mean, wouldn't he have gotten rid of me a long time ago? I mean, wouldn't he have the decency to get rid of such concentrated evil like me? No! No! There is no dreamer, and evil. Always. Wins. Thus showing that there is no good in the world, and evil is always rewarded. That's the way it is, and that's the way I always (poof)
On the final episode of Robo Girl the villain is explaining the mind-screwing origin of The Host to the protagonist when she grabs her throat, saying, "You talk too much!"
Lex Luthor: Say goodbye to the world you know! From this moment on, you are all at the mercy of Lex Luthor, the greatest criminal mind of our—
Green Goblin: AHHHH, SHUT UP! (knocks him down with a pumpkin bomb)
At the end of Spoony's review of Ultima IX, the Guardian offers Spoony three choices: destroy the Black Gate, eventually driving away his friends and fans; embrace madness and end humanity's suffering through death; or go through the Black Gate and become one with the Guardian, their combined power making any world theirs for the taking. Spoony responds with a seeming non-sequitir:
Guardian: I guess we all know how this ends, don't we Avatar?