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Anime And Manga
- Franken Fran has Fran Madaraki, a cute Frankenstein's Monster. While she was most likely (erroneously) named after the monster, she still fits the trope on virtue of being an expert surgeon that creates horrors of her own.
- Soul Eater has Dr. Franken Stein, another deliberate Expy and a typical Mad Scientist, albeit a heroic one.
- A more subtle example would be Franky from One Piece. After surviving a gruesome accident, he had to rebuild most of his body with mechanical parts from a ship, becoming a cyborg in the process (thus, following the theme of rebirth present in the Frankenstein novel).
- Dr. Franken von Vogler, from the Giant Robo OVA, is actually a subversion. He was introduced as a classic Mad Scientist at first, but turned out to be just a victim of bad PR.
- Blood Lad has a Dr. Franken who creates Akim Papladon, a demon that steals body parts of his liking.
- Runaways: Chase Stein's parents, Victor and Janet Stein, are a pair of Mad Scientists whose inventions are used by their son. The father's name should tell you everything.
- In Madman, the titular character's civilian identity is Frank Einstein. Supposedly, Doctors Flem and Boiffard named him for Frank Sinatra and Albert Einstein, but Frank is a resurrected dead man with a scarred face and bolts in the sides of his neck...
- In a Rantanplan comic, the titular dog and Averell Dalton are kidnapped by two scientists named Frank and Stein (the latter also having Einstein Hair).
- Professor Martin Stein is the man responsible for the reactor that created Firestorm. As such, he is often perceived this way (the 2004 run of the comic gives him Einstein Hair for good measure).
- An Elseworlds Superman one-shot story called Superman Monster had a version of Lex Luthor called Viktor Luthor. He finds some Krypton techology from the rocket that brought Kal-El to Earth and uses it to help him give life to a reconstructed human being.
- The main villain of the Madballs comic book published by now defunct Marvel Comics subsidiary Star Comics was a Mad Scientist named Dr. Viktor Frankenbeans.
Film — Animation
- Tim Burton's Frankenweenie, a remake of the 1984 short film of the same name, is both a parody and homage to the 1931 film Frankenstein. Frankenweenie is about a young filmmaker and scientist named Victor Frankenstein (natch) who brings his dog back to life.
- Dr. Finklestein from The Nightmare Before Christmas, Halloweentown's resident scientist and creator of Frankenstein's Monster-inspired Sally.
- In Scooby-Doo! Frankencreepy, Velma's original family name is revealed to be "von Dinkenstein" (it was changed to just "Dinkle" during immigration). Turns out she is also the descendant of a Mad Scientist and even ends up becoming one herself, although through hypnosis.
Film — Live-Action
- The Rocky Horror Picture Show has Dr. Frank-N-Furter, the infamous transvestite Mad Scientist played by Tim Curry.
- The House by the Cemetery has this as part of a twofer homage: the Mad Scientist villain is Dr. Freudstein. (This is a less certain example, though, as it is pronounced -steen).
- Jeffrey Franken from Frankenhooker is a "bio-electro technician" (whatever that means). He tries to revive his dead wife by reconstructing her body with pieces from dead hookers.
- Played with in Young Frankenstein: the name is spelled the same, but the pronunciation is "FRONK-in-Steen"
Live-Action — TV
- The Hilarious House of Frightenstein had the eponymous Count Frightenstein, complete with a Igor sidekick. He even had his own monster creation, Brucie.
- In Beetleborgs, Dr. Baron von Frankenbeans appears occasionally to check in on his creation (named simply "Frankenbeans").
- Helloween's "Dr. Stein" is a song about a monster-creating scientist.
- Victor Mordenheim from Ravenloft is a very transparent pastiche of Frankenstein.
- King K. Rool from the Donkey Kong Country series calls himself "Baron K. Roolenstein'' in the third game of the Rare trilogy.
- The Wario Land series has Mad Scienstein. Two guesses to what he does.
- Dr. Cranken from Viewtiful Joe 2 combines "Franken" with "Crank" and "Kraken", the creature he is based of.
- League of Legends has Viktor, a scientist champion who turned himself into a cyborg.
- Darkstalkers has Victor von Gerdenheim, the professor who created the series' playable Frankenstein's Monster that also shares the same name as his creator.
- Decap Attack has Dr. Frank N. Stein, who creates Chuck, the headless mummy player character, to battle a demon.
- Overwatch: Junkrat's mad scientist costume, "Doctor Junkenstein".
- Frankie and Stein is about child Mad Scientist "Stein" and his creation "Frankie".
- Frank from Two Guys and Guy is a sociopathic scientist who creates all sorts of devices, many of them of the apocalyptic kind.
- Dr. Vlad Stein from Blood Stain invokes the imagery of a typical Mad Scientist, with Einstein Hair, a dirty Labcoat of Science and Medicine and a scary, cliched name that references Dracula as well. Turns out he is just an Absent-Minded Professor.
- Runaway Brain features Dr. Frankenollie, a mad monkey scientist who swaps Mickey's brain with Julius', a Frankenstein's Monster that looks like Pete. He also ends up dying by crumbling into ash thanks to his experiment.
- A Goof Troop episode once involved Goofy inheriting a castle from Frankengoof, a family member. Naturally, a Frankenstein's Monster came along with the castle.
- Ben 10 has Dr. Viktor, a NASA scientist who is actually a Transylian, an alien race of Frankenstein's Monsters, working for Ghostfreak/Zs'Skayr, thus he ends up referencing both Frankenstein and his monster. When Ben turns into that race himself, the form was originally called Benviktor in the credits (alongside other unnamed monster forms "Benwolf" and "Benmummy") and later given the official name Frankenstrike.
- The Phineas and Ferb episode "The Monster Of Phineas-n-Ferbenstein" had Dr. Phineastein, an ancient Victorian scientist. He created his own monster, based on Perry The Platypus.
- While Professor Frink from The Simpsons is not an example (He's named after John Frink), there is a Treehouse of Horror episode where he revives his dead father. The episode is called "Frinkenstein".
- One of the last season episodes of Regular Show had minor character "Dr. Drodenstein'' ("Stein" was spelled as "Steen", but no one cared), a scientist who researched prank tools.
- I Am Weasel had I.M. Weasel playing Frankenweasel in an episode (actually a dentist who was trying to go back to his Mad Scientist roots), complete with I.R. Baboon as The Igor.
- The Oh Yeah! Cartoons short "Elise: Mere Mortal" featured an orthodontist named Dr. Toothinstein.