How to Train Your Dragon has the Night Fury, Toothless, easily the fastest dragon in flight, and with one of the most powerful fire blasts. Also, despite being comparatively small, he easily survives hitting the ground any time he gets shot down or loses control of his flight.
Chien-Po may look like a Big GuyMighty Glacier, (and he shows himself to be just as strong as he looks,) but he's as agile as a monkey.
Considering that Shan Yu is able to trade blows with him during the climax, he might also count, albeit as the "hard-hitting speedster" type, rather than the "fast big guy" type.
The title character of Wreck-It Ralph is fairly fast, able to wreck things so quickly that his fists act like a pair of jackhammers. Also, King Candy's Cy-Bug form has enough power to smack down Ralph of all people, and he's shown to be remarkably fast.
Bane's portrayal in The Dark Knight Rises demonstrates this as well. In the stock exchange raid, he uses a motorcycle helmet to knock out three security guards in under seven seconds. Also, while strong enough to punch holes in concrete, he has incredible reflexes and speed to match up with Batman.
Obadiah Stane/Iron Monger in the Iron Man film could be considered one of these; his suit is fast enough to catch up with Tony's despite Tony's smaller suit and head-start, while also being stronger to boot.
The second Iron Man film has Ivan Vanko, able to hit professional racecars with his whips and faster than both Tony and Rhodey in his suit at the end. And Tony's new Arc Reactor means he doesn't have the excuse of being low on power! His bruiser qualities are self-evident.
Thor is a literal version of this trope because he is the God of Thunder and Lightning. He's strong enough to throw his hammer through multiple Frost giants at a time, one hit almost all of them with a lighting strike created earthquake and smash through the back of an enormous monster's head. And he flies. Very, very fast.
The Incredible Hulk in The Avengers is remarkably fast for a huge green rage monster, and it's quite evident during the final battle, when he's just plowing through the alien forces with amazing agility.
Danny Bateman in The Replacements. He plays on the defensive line, so you expect him to be strong. What you don't expect, is him crashing through the other team's blockers after the snap, and tackling the quarter-back before he's had the chance to take two steps back. The guy's day job? A one-man SWAT team.
The droideka in Star Wars. It can roll into a ball and move at ridiculous speed, and when it unrolls, it's protected by a deflector shield and a pair of rapid-fire blaster cannons. In the films, they could drive off even Jedi. Its weakness? It can't deflect or shoot while it's rolling around, and it often has to lose the shield to reduce expenses. It's also revealed in the Revenge of the Sith novelization that their shields are precisely tuned to be used only when standing upright, so if one can be knocked over, its generator will short out.
Yoda. Able to fight the kriffing Sith'ari to a draw, and he's all over the place during the fight—you'll hit where he was half a grimnal ago.
The Transformers are incredibly fast and graceful despite being made of huge, durable metal parts.
The Terminator is fast and incredibly tough, and the later movies showed them getting progressively faster and meaner. Between the original, Uncle Bob, the T-1000, the T-X, Cameron, Cromartie, Catherine Weaver, and Marcus, there's no shortage of these tough, fast, and very literal killing machines.
All robots in Real Steel are big, armored, and heavy. And yet they move no different than a heavyweight boxer. Atom even more so, as he is smaller than an average fighting bot (but still bigger than a human), while possessing a lot more armor (he can shrug off punches that shatter latest-generation contenders).
In Kung Fu Hustle, The Beast is super strong and super fast even by the standards of the martial artists in the film. He demonstrates this to the Axe Gang who initially underestimate him due to his appearance by firing a handgun a few inches from his head and catching the bullet.
In Star Trek: Into Darkness, Admiral Marcus commissions the U.S.S. Vengeance, a beast of a starship (called "Dreadnought-class" in-movie) that is designed to run down enemy starships while at warp and tear them to shreds.
Big BadSuper Soldier John Harrison aka Khan Noonien Singh also qualifies, being the physically strongest character in the film series seen so far, as well as being lightning fast in close combat.
In Ip Man 2, the Twister is not only as fast as Master Hung and Ip, but stronger and tougher. He holds the distinction of being the only character to knock Ip down onscreen.
The Australian Jaeger, Striker Eureka from Pacific Rim. Despite being the fastest of any of the unveiled Jaegers, it's easily a match in strength and durability to the Mighty Glacier Russian Jaeger that out masses it by 560 tons. That said, considering size and scale of the Jaegers, 560 isn't a massive difference in weight.
Justified, Cherno may have about 30% more mass than Striker, but Striker has four generations on Cherno.
Elysium: Max, Kruger, Drakey, and Crowe all qualify.
The Chronicles of Riddick: Despite his size and weight, Riddick is incredibly quick on his feet and is capable of performing amazing feats of physical athleticism, such as leaping great distances, running without stop for long periods of time and being strong enough to go toe to toe with a Bioraptor and mutilating it.
True to her species, Gloria the hippo of Madagascar is capable of running great speeds despite her bulk. It's carried over to the video games, where jalapeņos can be used to boost her speed.
Martin Brundle/Martinfly from The Fly 2 after he fully mutates. Unlike his father in the first film (who got his genes mashed together with those of a fly, which slowly transformed him into strong, but sickly and asymmetrical mostrocity), Martin was born with those genes, meaning not only he's completely lucid, but his insect form is much more natural and viable. He's remarkably fast and capable of leaping great distances, strong enough to fold a grown man in half (backwards) and toss another one across the room, and a bullet to the torso only very temporary slows him down, if he wasn't outright feigning injury.