George: A 'slight accident?'. A radiation leak is a slight accident. THIS IS @#^!# SCROOGE MCDUCK ON A POGO STICK!
Bob: GOD I HATE THIS COMIC! WHY CAN'T ANYONE JUST DIE?!
George: Bob...Bob died a hero? *Cue messed-up panels* Oh great, I'm insane again.
The moment during the Robot Tournament after George loses his time machine and Megaman tells him he has lost his only chance to go back to his own time. George's reaction is hilarious.
George's Painful Realization and the ensuing comics. One of the few times where 2+ consecutive comics used no dialogue and it was enough to make this troper roll on the floor laughing.
Charge Man's master plan to defeat Mega Man which combines his original plan with Wave Man's and Stone Man's. It's drawn in crayon and by its very flawed design, would kill him as well.
In the robot tournament arc for the 6th game, Dave had Snake Man and Ring Man oppose each other in one fight because they were the least quirky Robot Masters in the entire comic. The next day, in the comments, Dave mentions that he was completely unaware of "the obvious relationship between rings and snakes" until several fans constantly e-mailed him about the topic.